MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02807cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
161204s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2016.Gh.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ghada Emam Abdelaziz |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Impact of toll-like receptor 9 gene polymorphism (1237 t / c) on response to therapy in chronic hepatitis C Egyptian patients / |
| Statement of responsibility, etc. |
Ghada Emam Abdelaziz ; Supervised Doha Abdelhamid Mokhtar , Rania Ahmed Ahmed Zayed , Dalia Abdelhamid Omran |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
على الاستجابه للعلاج في المرضى المصريين المصابين بالالتهاب الكبدي الوبائي سي(T/C 1237) أثر التعدد الشكلى لجين مستقبل شبيه التول 9 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ghada Emam Abdelaziz , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
122 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background and aim: Hepatitis C virus (HCV) infection leads to development of liver inflammation, causing morbidity and mortality. Multiple factors influence HCV progression, including genetic factors. Toll-like receptor 9 (TLR9) plays a key role in innate immunity and mutations in the genes encoding this receptor have been associated with progression of liver damage. Our aim is to detect TLR9 1237 T/C (rs5743836) single nucleotide polymorphisms (SNP) in chronic hepatitis C Egyptian patients to determine its association with susceptibility to infection, progression of fibrosis and response to treatment with interferon plus ribavirin. Results: genotype and allelic frequencies of TLR9 1237T/C SNP were not significantly different between studied HCV-positive patients and controls (P=0.373 and 0.405, respectively). TLR9 1237T/C SNP was not associated to treatment response, either ETR or SVR [OR (95% CI) of 0.834 (0.263{u2013}2.643) and 0.698 (0.253{u2013}1.928), respectively) and was not related to advanced stage of fibrosis (P= 0.183). Baseline AFP level was significantly higher in patients with advanced hepatic fibrosis (P= 0.000). Conclusion: TLR9 1237T/C (rs5743836) SNP is not associated to susceptibility to HCV infection, progression of fibrosis or response to combined treatment with Peg-INF plus ribavirin in HCV infected Egyptian patients. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
TLR9 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Abdelhamid Omran , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Doha Abdelhamid Mokhtar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rania Ahmed Ahmed Zayed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Soheir |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
