Effect of glucagon like peptide-1 analogue (exendin-4) and metformin on cognitive functions in type 2 diabetic male rats; possible modulation of visfatin and brain derived neurotrophic factor / (Record no. 59586)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02770cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031643.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170124s2016 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2016.Om.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omaima Mohammed Abdelwahed Awadallah |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of glucagon like peptide-1 analogue (exendin-4) and metformin on cognitive functions in type 2 diabetic male rats; possible modulation of visfatin and brain derived neurotrophic factor / |
| Statement of responsibility, etc. | Omaima Mohammed Abdelwahed Awadallah ; Supervised Maha Mohamed Gamal Eldin , Ola Mostafa Tork , Maha Baligh Zickri |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تاثير نظير الببتايد 1الشبيه بالجلوكاجون (الاكسندين 4) و الميتفورمين على الوظائف المعرفية فى ذكور الفئران المصابه بالنوع الثانى من داء السكرى احتمالية التغير فى الفسفاتين و عامل التغذيه العصبية المستمد من الدماغ |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omaima Mohammed Abdelwahed Awadallah , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 275 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study was designed to investigate the changes in cognitive functions in type 2 diabetes mellitus (T2DM), either not treated or treated with metformin antidiabetic drug, glucagon-like peptide 1 (GLP-1) analogue: exendin-4 (Ex-4) or both and to identify the possible underlying mechanisms and whether the brain BDNF and brain visfatin are involved. T2DM resulted in a negative impact on cognitive functions may be through central and peripheral inflammatory mechanisms, induction of a state of oxidative stress and neurodegeneration, downregulation of BDNF expression and synaptophysin immunoexpression in brain tissue in addition to the direct deleterious effects of hyperglycemia and insulin resistance. Upregulation of visfatin with induction of T2DM in the current study could be a compensatory mechanism aiming to reverse these harmful effects of T2DM. Treatment of T2DM with metformin and/or exendin-4 significantly reversed effects of T2DM on the measured parameters and partially restored cognitive functions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cognitive functions |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Exendin-4 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 2 diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Baligh Zickri , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Mohamed Gamal Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mostafa Tork , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2016.Om.E | 01010110070794000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2016.Om.E | 01020110070794000 | 22.09.2023 | CD - Rom | 70794.CD |