Assessing the relation between hormone receptors gene polymorphism and ovarian stimulation response in vitro fertilization (IVF) program / (Record no. 59587)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03306cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031643.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170124s2016 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.M.Sc.2016.Na.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nadine Wagdi Maurice |
| 245 10 - TITLE STATEMENT | |
| Title | Assessing the relation between hormone receptors gene polymorphism and ovarian stimulation response in vitro fertilization (IVF) program / |
| Statement of responsibility, etc. | Nadine Wagdi Maurice ; Supervised Tarek Mohamed Kamal Motawi , Sherine Maher Rizk , Wael Tharwat Elgarf |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحديد العلاقة بين تعدد الشكل الجينى لمستقبلات هرمون المبيض و استجابة المبيض للتحفيز اثناء برنامج عملية التخصيب المخبرى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nadine Wagdi Maurice , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 Leaves : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In vitro fertilization (IVF) is highly challenged by the erratic individual variability to controlled ovarian hyperstimulation (COH). This study aimed at implementing the role of pharmacogenetics in predicting the stimulation success and thus tailoring the treatment reaching advancement in patient care. The follicle stimulating hormone receptor (FSHR) and the estrogen receptors (ERs) are important genes in explaining the variability in COH results. We performed a prospective study on 216 young women with unexplained infertility. Ovarian stimulation was performed according to the gonadotropin-releasing hormone antagonist (GnRHant) protocol with a fixed daily morning dose of human menopausal gonadotropin (HMG) intra muscular injection starting on cycle day 2. Based on the patient{u2019}s body mass index (BMI) and hormonal profile, the daily dose of HMG was adjusted. The ESR2 (+1730G > A) (rs4986938), FSHR p.Thr307Ala (c.919A > G, rs6165) and FSHR p. Asn680Ser (c.2039A > G, rs6166) single nucleotide polymorphisms (SNPs) were detected by real-time polymerase chain reaction. Serum FSH, estradiol (E2) and anti mullerian hormone (AMH) levels were measured by enzyme linked immunosorbent assay (ELISA). This study revealed that the low AMH level was highly significantly related to the poor ovarian response (p < 0.001). Furthermore, the frequency of the ESR2 (AA) genotype and the FSHR (Ala307Ala), (Ser680Ser) genotypes were highly significantly associated with the poor ovarian response (p < 0.001). In the combined analysis of FSHR and ESR2 genes, the more specific haplotypes were (AAG) for good responders and (GGA) for poor responders. In conclusion, the AMH level in combination with the ESR2 and the FSHR gene polymorphisms predict the poor ovarian response to COH in Egyptian women |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hormone receptors gene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IVF |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ovarian stimulation response |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherine Maher Rizk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Mohamed Kamal Motawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Tharwat Elgarf , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.M.Sc.2016.Na.A | 01010110070795000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.M.Sc.2016.Na.A | 01020110070795000 | 22.09.2023 | CD - Rom | 70795.CD |