MARC details
| 000 -LEADER |
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| fixed length control field |
03341cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170322s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.Ph.D.2016.Lo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lobna Hatem Abdelghaphour Khedr |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effects of fluoxetine and pentoxifylline on stress-induced changes in the molecular paradigm of mitochondrial regulation in the hippocampus of male wistar rats / |
| Statement of responsibility, etc. |
Lobna Hatem Abdelghaphour Khedr ; Supervised Ezzeddin Said Eldenshary , Ahmed M. Abdeltawab , Laila Rashed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثيرات الفلوكستين و البنتوكسيفلين في تغيرات محدثة بالكرب في نموذج جزيئي لنظام الميتوكوندريا في قرن آمون لذكور جرذان " ويستر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Lobna Hatem Abdelghaphour Khedr , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
214 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Previous reports in our lab linked chronic mild stress (CMS), a well-validated model of depression, to impaired hippocampal energy metabolism and mitochondrial dysfunction. Adding repeated lipopolysaccharide (LPS) to CMS was recently proposed as another model of depression. The combined LPS/CMS model highlighted the possible interaction between stress and immune-inflammatory pathways and their impact on disrupting tryptophan metabolism and triggering TNF-Ü induced changes in the hippocampus along with depressive-like behavioral alterations. In the current study, the interplay between mitochondrial biogenesis and toll-like receptor 4 (TLR4) signaling, as a target for LPS, was investigated in a combined LPS/ CMS model. To this end, male Wistar rats were exposed to either LPS (50 og/kg i.p) over 2 weeks, CMS protocol for 4 weeks or LPS over 2 weeks followed by 4 weeks of CMS (LPS/CMS). Another three groups of rats were exposed to LPS/CMS protocol and treated with either pentoxifylline (PTX), fluoxetine (FLX) or a combination of both. Rats were examined for behavioral, neurochemical, gene expression and mitochondrial ultra-structural changes.Animals exposed to LPS/CMS showed perturbation of serum corticosterone (CORT) and {u2018}TNF-Ü{u2019} levels as well as behavioral responses. Interestingly, LPS/CMS attenuated the increased expression of TLR4 and its downstream players; MyD88 adaptor protein, nuclear factor kappa B (NFmB) and hippocampal TNF-Ü, compared to SAL/CMS. Moreover, LPS/CMS abridged the SAL/CMS effects on mitochondrial biogenesis machinery; peroxisome proliferator-activated receptor gamma co-activators1-alpha (PGC1-Ü). Furthermore, the antidepressant (AD) {u2018}FLX{u2019}, the TNF-Ü inhibitor {u2018}PTX{u2019} and their combination engendered a further enhancement in all the aforementioned LPS/CMS-induced changes (figure 1) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CMS |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
LPS |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
TLR-4 signaling |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Moheyeldin Abdeltawab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ezzeddin Said Eldenshary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Laila Rashed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
