TRAIL receptor 1 (DR4) polymorphisms C626G and A683C with hepatocellular carcinoma in Egyptian population / (Record no. 59696)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02831cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031646.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170206s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2016.Na.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nagla Fathy Elsalawy |
| 245 10 - TITLE STATEMENT | |
| Title | TRAIL receptor 1 (DR4) polymorphisms C626G and A683C with hepatocellular carcinoma in Egyptian population / |
| Statement of responsibility, etc. | Nagla Fathy Elsalawy ; Supervised Ahmad Elsayed Eltaweel , Manal Mohammad Kamal , Tamer Mahmoud Baz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | العلاقة بين التعدد الجينى فى التريل جين 1(دى ار 4) فى سى 626جى و اى 683 سى مع سرطان الكبد فى المجتمع المصرى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nagla Fathy Elsalawy , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 158 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma is the most common primary tumor of the liver. The molecular determinants of the HCC progression are still under investigations. TRAIL receptor 1 plays a very important role in many types of cancers including HCC. Genetic polymorphisms of TRAIL DR4, can modulate death signal transduction, which is important in induction of apoptosis and cause increase in the tumor progression. The aim of the present study was to investigate the effect of the DR4 polymorphisms C626G (Thr209Arg, rs20575) and A638C (Glu228Ala, rs20576) on the occurrence of hepatocellular carcinoma in Egyptian patients chronically infected with HCV. Genotyping of the candidate genes was performed by real time PCR assay in 80 HCC patients on top of HCV infection, and 80 HCV patients. The frequency distribution of rs20575 genotypes showed a statistically significant difference between the two studied groups (p = 0.020), the carriers of the C allele were 2.01 times more likely to develop HCC than the carriers of the G allele (p = 0.003), while no significant difference in rs20576 genotypes distribution was found between the studied groups (p = 0.680). On combining the carriers of C allele of rs20575 and the carriers of A allele of rs20576, a significant difference was detected (p > 0.001) with 2,85 higher risk of HCC development in patients who carried both genetic risk alleles simultaneously |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | C626G and A683C |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TRAIL 1 DR4 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmad Elsayed Eltaweel , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal Mohammad Kamal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tamer Mahmoud Baz , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2016.Na.T | 01010110071017000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2016.Na.T | 01020110071017000 | 22.09.2023 | CD - Rom | 71017.CD |