miRNA 101-1 and miRNA 221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma / (Record no. 59704)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02569cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031646.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170206s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2016.Ma.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maha Mohamed Salah Eldin |
| 245 10 - TITLE STATEMENT | |
| Title | miRNA 101-1 and miRNA 221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma / |
| Statement of responsibility, etc. | Maha Mohamed Salah Eldin ; Supervised Olfat Gamil Shaker , George Nazih Bishara Morcos , Aisha Mahmoud Abdelaziz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعبير و التحور الجينى فى الميكرو أر إن إيه 1- 101 و221 كدلالات حيوية تنبؤية للتشخيص المبكر لسرطان الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Maha Mohamed Salah Eldin , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor with an increasing incidence. HCV is one of the major risk factors that lead to HCC development. MicroRNAs are conserved non-coding RNAs which regulate gene expression at the posttranscriptional level. They have been recently identified as important regulators that affect carcinogenesis. Of these miRNAs, are miR 221 and miR 101-1, which their aberrant expressions have been reported to play an important role in HCC. In this study, we aimed to investigate the association between miR-221 and miR-101-1 polymorphisms and their expressions and the early prediction of HCC in HCV infected patients. First, RNA was extracted from serum using (qiagen, valencia, CA, USA) then quantitative real-time PCR (qPCR) was done to estimate the expression levels of miRNA 221 and miRNA 101-1 in serum. To detect the genotyping of miR 221 and miR-101-1 related SNPs, DNA was extracted from whole blood using Qia amplification DNA extraction kit (qiagen, USA). Then, genotyping was performed using real-time PCR with TaqMan allelic discrimination assay Applied Biosystems, USA |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | miR 101-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aisha Mahmoud Abdelaziz , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | George Nazih Bishara Morcos , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.M | 01010110071021000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.M | 01020110071021000 | 22.09.2023 | CD - Rom | 71021.CD |