Cognitive impairment in schizophrenia and genetic expression of GABA using human induced pluripotent stem cells / (Record no. 59718)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02547cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031647.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170207s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.21.Ph.D.2016.Da.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dalia Khalifa Zayet |
| 245 10 - TITLE STATEMENT | |
| Title | Cognitive impairment in schizophrenia and genetic expression of GABA using human induced pluripotent stem cells / |
| Statement of responsibility, etc. | Dalia Khalifa Zayet ; Supervised Mahmoud Elbatrawi , Hala Gabr , Heba Fathy Eid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الاضطراب المعرفى لمرضى الفصام و التعبير الجينى للجابا بإستخدام الخلايا الجذعية المتحوره المحفزة بواسطة الأنسان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dalia Khalifa Zayet , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 220 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Neurotransmitters in general and GABA in particular are very important in normal cognition and the alteration of GABergic neurotransmission is accused to be sharing in the cognitive impairment in schizophrenia. GABA is the main inhibitory neurotransmitter in the brain. Its role in cognitive functioning is mediated through its effect on neurodevelopment, on fast synaptic transmission and also on gamma band synchronization. Exploring the molecular changes and cellular genetic expression of GaBergic genes is an essential step to know more about the real functioning of GABA in patients presenting with schizophrenia. Measure the genetic expression of (GAD65), GAD67, GABA beta2 and (mGLUR7) in patients presenting with schizophrenia and finding possible correlation with cognitive functions. Modeling of schizophrenia through human induced pleuripotent stem cells (hIPSc) through reprogramming of fibroblasts into hIPSc followed by neuronal differentiation. Real time PCR was used for measurement of genetic expression. Subtests of wechsler intelligence, trail A and B and rey ostrich test were used to assess cognitive functions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GAD 65 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genetic expression |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Human induced pluripotent stem cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Gabr , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Fathy Eid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Elbatrawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.21.Ph.D.2016.Da.C | 01010110071040000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.21.Ph.D.2016.Da.C | 01020110071040000 | 22.09.2023 | CD - Rom | 71040.CD |