Hemochromatosis gene polymorphism as a predictor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus / (Record no. 59836)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03378cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170214s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.M.Sc.2016.Kh.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khadiga Mahmoud Mostafa |
| 245 10 - TITLE STATEMENT | |
| Title | Hemochromatosis gene polymorphism as a predictor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus / |
| Statement of responsibility, etc. | Khadiga Mahmoud Mostafa ; Supervised Dina Sabry Abdelfattah , Naglaa Adly Abdelazeem , Mai Ismael Mehrez |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | استخدام الهيموكروماتوزيس جين كوسيلة تنبؤية للاستجابة للانترفيرون طويل المفعول والريبافيرين في علاج مرضى فيروس سي الكبدي المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Khadiga Mahmoud Mostafa , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 131 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim of the work: The aim of this work is to assess the value of HFE (C282Y) gene mutations as a predictor of virological response to Pegylated interferon plus ribavirin in treatment of Egyptian patients with chronic hepatitis C virus infection.Methods: One handered and forty CHC patient were treated by pegylated interferon (IFN) Ü2a and Ü2b plus ribavirin for 48 weeks, quantitative PCR at week 12th and qualitative PCR at week 24th and 48th will be done for all patients who were divided into 2 groups as: GROUP (1): Patients with end of treatment virological response (ETR),GROUP (2): 70 patients with non virological response subjected to Anti HCV Ab, Baseline HCV RNA, Qualitative HCV RNA PCR at week 12 and quantitative HCV RNA PCR at weeks 24, 48 and 72 weeks after treatment , DNA sequencing. and Molecular study for HFE (C282Y) by RFLP PCR. Result: HFE gene mutation (C282Y) was detected in 54 patient (38.5%) and the presence of c282y mutation was significantly associated with elevated iron parameter (TS (p value <,001), S iron (p value ,02), TIBC (p value<.,001), transferrin (p value ,016) and sTfR ( p value ,001) but no significant difference as regard ferritin(p value ,76) and c282y mutation present frequently in non response group; 65 of 70 patient (92,9%) of response group have gene without mutation(GG) and only 5 patient(7%) carry c282y mutation (GA), while 45 of 70 (64,3%) of non responders carry heterozygous c282y mutation (GA), 4 patient (5,7%) carry homozygous mutation(AA) and 21 patient (30%) are without mutation (GG) , there was a statistically significant difference between groups as regard HB with p value 0.027 In conclusion, Iron overload was frequenty detected in CHC patient and associated with c282y mutation ,Biochemical markers of iron overload and c282y HFE mutation were negative prognostic factor for treatment of CHC by interferon and ribavirin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chronic hepatitis C |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hemochromatosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interferon |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfattah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Ismael Mehrez , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Adly Abdelazeem , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shaima |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.M.Sc.2016.Kh.H | 01010110070862000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.M.Sc.2016.Kh.H | 01020110070862000 | 22.09.2023 | CD - Rom | 70862.CD |