Tissue expression of aquaporin 3 in psoriatic patients before and after treatment with oral retinoids and photochemotherapy / (Record no. 59863)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03233cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170215s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2016.Ma.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Ahmed Mohamed Ali Amer |
| 245 10 - TITLE STATEMENT | |
| Title | Tissue expression of aquaporin 3 in psoriatic patients before and after treatment with oral retinoids and photochemotherapy / |
| Statement of responsibility, etc. | Marwa Ahmed Mohamed Ali Amer ; Supervised Shahira Abdelrahman Ramadan , Ola Mohammad Abuzeid , Nevine A. Dorgham |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ًًنمط أكوابورين 3 في الأنسجة في مرضي الصدفية قبل و يعد العلاج بالرتينونيدات بالفم و العلاج بالأشعة فوق البنفسجية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Ahmed Mohamed Ali Amer , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 182 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study included forty patients with psoriasis, twenty patients received PUVA and the other twenty received retinoids. Twenty healthy , age and sex matched, controls were also included. Each patient was subjected to short medical history and cutaneous examination. Skin biopsies from the lesional and perilesional skin of each case were examined and immunohistochemical study was done using anti aquaporin 3 antibodies before and after treatment with PUVA and retinoids.The same was applied to biopsies from healthy controls.Results: AQP3 stained both the psoriatic and normal epidermis in both the basal and spinous layers. No staining reaction was detected within the stratum corneum in all cases and controls. Among psoriasis patients, there were a significantly higher number of biopsies showing cytoplasmic pattern of AQP3 in the spinous layers compared to control (P value = <0.001). Moreover, the cytoplasmic expression of AQP3 in the spinous layer was also significantly higher than control (P value = < 0.001). Exposure to PUVA didn{u2018}t cause significant change in the membranous as well as the cytoplasmic expression of AQP3 in the lesional skin. Retinoids reduced the cytoplasmic expressions of AQP3 to approach normal control values. Conclusion: In psoriatic epidermis, the abnormal cytoplasmic location of AQP3 may affect its function and together with its over expression may lead to increased TEWL and dryness of the lesion. The high expression of AQP3 can be related to hyperproliferation of the epidermis and increased T cell traficking . Treatment with PUVA didn{u2018}t affect the cytoplasmic location of AQP3. On the other hand, treatment with retinoids almost normalized the AQP3 cytoplasmic expression.This suggests that AQP3 can be a theraputic target for retinoids in psoriasis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Clinical |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Histopathology |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Psoriasis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Ahmed Dorgham , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohammad Abuzeid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Abdelrahman Ramadan , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2016.Ma.T | 01010110070897000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2016.Ma.T | 01020110070897000 | 22.09.2023 | CD - Rom | 70897.CD |