MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02987cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170227s2016 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.06.M.Sc.2016.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shaimaa Moustafa Haikal |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The effect of treatment with mesenchymal stem cells on mice treated with collagen induced arthritis : |
| Remainder of title |
Possible role of interleukin 4 / |
| Statement of responsibility, etc. |
Shaimaa Moustafa Haikal ; Supervised Magdy Ali Amin , Laila Ahmed Rashed , Nourtan F. Abdeltawab |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير العلاج بالخلايا الجذعية الوسيطة على الفئران المعالجه بالكولاجين المسبب لمرض التهاب المفاصل : |
| Remainder of title |
الدور المحتمل للانترليوكين4 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shaimaa Moustafa Haikal , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
83 P. : |
| Other physical details |
photographs ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Rheumatoid arthritis (RA) is a debilitating disease causing decreased quality of life. The disease affects primarily small joints of the hands and feet and is classified as a chronic autoimmune disorder. Mesenchymal stromal cells (MSCs) have been shown to exert immunosuppressive activity with the possibility for use in the treatment of RA. Similarly, interleukin (IL)-4 has been investigated as a possible RA treatment. Therefore, in the current study, we aimed to investigate the effect of combination therapy of bone marrow-derived MSCs (BM-MSCs) and IL-4 as a possible treatment of murine collagen-induced arthritis (CIA). We induced arthritis in Balb/c mice by intradermal injection of 100 æg of type II collagen (CII) at day 0 and 21 and mice were examined daily for the onset of clinical manifestations of arthritis. Mice were divided into four groups, first group received intravenous injection (i.v.) of MSCs only, second group received intraperitoneal injection (i.p.) of IL-4 only, and a third group received i.v. and i.p MSCs and IL-4 respectively. A fourth CIA control group received PBS after induction of arthritis. In addition, a fifth group of untreated mice served as healthy controls. After four weeks of treatment, we collected blood from each group and mice were sacrificed and synovial tissue was examined. RA was evident in CIA control group by histopathological examination of knee joints that showed erosions of articular cartilage, edema and influx of inflammation compared to healthy controls |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Collage induced arthritis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Mesenchymal stromal cells (MSCs) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Rheumatoid arthritis (RA) |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Laila Ahmed Rashed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Magdy Ali Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nourtan F. Abdeltawab , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
