Formulation and evaluation of anti-vomiting drug in a nasal drug delivery system / (Record no. 60032)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02938cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031656.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170228s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2016.El.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Elshimaa Mohamed Attia |
| 245 10 - TITLE STATEMENT | |
| Title | Formulation and evaluation of anti-vomiting drug in a nasal drug delivery system / |
| Statement of responsibility, etc. | Elshimaa Mohamed Attia ; Supervised Mohamed Ahmed Elnabarawi , Rehab Ahmed Abdelmonem Hassan |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | صياغة و تقييم عقار مضاد للقئ فى شكل صيدلى لتعاطيه عن طريق الأنف |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Elshimaa Mohamed Attia , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 136 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Nausea and vomiting are common symptoms in patient receiving chemotherapy. More than 70% of the patient treated with chemotherapy experienced nausea and vomiting. It is thought that chemotherapeutic agents cause vomiting by activating neurotransmitter receptors located in the chemoreceptor trigger zone (CTZ), gastrointestinal (GI) tract, and vomiting center. Serotonin (5- hydroxyl tryptamine [5-HT3]) and dopamine receptors are the primary neuro receptors involved in the emetic response, particularly the 5- HT3 receptor. Granisetron hydrochloride is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). It is hydrophilic drug which limits its uptake to the brain cells it has poor oral bioavailability (60%) due to its first pass hepatic metabolism. Nasal application circumvents {uFB01}rst pass elimination, degradation and irritation in GIT, and may be employed routinely without any pain, since it is noninvasive therefore, reduced risk of infection as compared to IV administration. Furthermore, studies demonstrated the existence of direct transport from the nasal cavity to the cerebrospinal {uFB02}uid and proceeding to the brain. Other advantages of intranasal route are to reduce risk of the over doses (high bioavailability at low doses) and easy of self-medication so it improves patient compliance. The aim of this work was to develop GH spanlastic loaded in a nasal delivery system for enhancing brain delivery of GH to give a higher bioavailability |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Granisetron hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nasal gel |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Spanlastic dispersions |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ahmed Elnabarawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rehab Ahmed Abdelmonem Hassan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2016.El.F | 01010110071147000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2016.El.F | 01020110071147000 | 22.09.2023 | CD - Rom | 71147.CD |