MARC details
| 000 -LEADER |
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| fixed length control field |
03388cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170308s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.03.Ph.D.2016.Di.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dina Mohamed Mekawy Rabie |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effects of administration of mesenchymal stem cells with and without PPAR-Þ agonist and Exendin-4 on mitochondrial dysfunction in diabetic cardiovascular complications in rats / |
| Statement of responsibility, etc. |
Dina Mohamed Mekawy Rabie ; Supervised Mohamed Abdelaziz Wassef , Ola Mostafa Tork , Walaa Ibrahim Ali |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثيرإضافه الخلايا الجذعية مع أو بدون محفزات البابار-جاما و الإكسيندين-٤ على الخلل الوظيفى للميتوكوندريا فى مضاعفات القلب لمرض البوال السكرى فى فئران التجارب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Dina Mohamed Mekawy Rabie , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
204 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Diabetic cardiomyopathy (DCM) is defined as the cardiovascular damage present in diabetic patients, which is characterized by myocardial dilatation and hypertrophy, as well as a decrease in the systolic and diastolic function of the left ventricle. Therapy targeting mitochondria may provide novel ways to treat diabetes or to minimize the complications of diabetes or both. The PPAR agonists, in addition to their insulin-sensitizing properties,they have potential to affect cardiovascular disease risk in patients with type 2 diabetes .Bone marrow derived mesenchymal stem cells (MSCs) have shown great potential in cell therapy of solid organs. Exendin-4 is an analog of glucagon-like peptide-1(GLP-1). It promotes insulin gene transcription, synthesis and secretion. It inhibits the apoptosis of pancreatic Ý-cells at the gene level and promotes proliferation and regeneration. So we designed this work to evaluate the effect of MSCs, PPAR Þ agonist and Exendin-4 on diabetic cardiomyopathy. Methods: This work included: one hundred and five rats which were divided equally into seven groups: healthy control group, diabetic group that was induced by streptozotocin, diabetic group received MSCs only, diabetic group received Pioglitazone(PPAR Þ agonist) only, diabetic group received both MSCs and Pioglitazone, diabetic group received Exendin-4 only, diabetic group received both MSCs and Exendin-4 . Histopathological examination, gene expression of light chain 3(LC3), beclin, PGC alpha, nuclear factor kappa-light- chain-enhancer of activated B cells (NFmB) and Myocyte enhancer factor- 2 (Mef2) genes by real time reverse transcription-polymerase chain reaction (RT-PCR) in rat heart tissue, uncoupler protein 2 (UCP2) by western blot technique, serum levels of Mitochondrial cardiolipin and insulin by ELISA were assessed |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Diabetic cardiomyopathy |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
PPAR у |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Abdelaziz Wassef , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ola Mostafa Tork , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walaa Ibrahim Ali , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shaima |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
