Effect of CYP3A4 gene polymorphism on statin therapy / (Record no. 60241)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02749cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031702.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170314s2016 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2016.En.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Enas Elsayed Tawfiek Elsayed |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of CYP3A4 gene polymorphism on statin therapy / |
| Statement of responsibility, etc. | Enas Elsayed Tawfiek Elsayed ; Supervised Ahmed Abdelbary Abdelrahman , Sherif Mokhtar , Sanaa Abdelshafy |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Enas Elsayed Tawfiek Elsayed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 92 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Statins (HMG-CoA reductase inhibitors) are today accepted as the treatment of choice for lowering low density lipoprotein cholesterol (LDL-C) in the vast majority of individuals with increased risk for cardiovascular disease (CVD) and associated mortality. One of regularly used statins atorvastatin is mainly metabolized by cytochrome P450 (CYP) 3A4 enzyme, genetic variation within the CYP3A4 gene may lead to variation in CYP3A4 activity and, in turn, to the difference in the metabolism and, ultimately, the variable response of atorvastatin. The aim of this study is to determine whether the CYP3A4*1G gene polymorphisms affect lipid-lowering efficacy of atorvastatin (80 mg / day) after 4 weeks of treatment and prevalence of these polymorphisms in the Egyptian patients. Patients and methods In a prospective observational non-intervention randomized open labeled study, forty eight critically cardiac ill Egyptian patients admitted with an acute coronary syndrome (myocardial infarction) who were susceptible to intensive atorvastatin dose (80 mg) treatment were selected during the period from July 2011 to May 2015 to be enrolled in the present study. Genomic DNA was extracted from WBCs and CYP3A4*1G genotyping was done using a polymerase chain reaction restriction fragment length polymorphism (PCR- RFLP) analysis. The fragments containing 1/1, 1/1G and 1G/1G polymorphism were amplified. Serum triglyceride (TG), total cholesterol (TC), and high density lipoprotein cholesterol (HDL-C) levels were determined at baseline and after 4 weeks of treatment by enzymatic assays |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Atorvastatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CYP3A4 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gene polymorphisms |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelbary Abdelrahman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelshafy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Mokhtar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2016.En.E | 01010110071282000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2016.En.E | 01020110071282000 | 22.09.2023 | CD - Rom | 71282.CD |