MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02852cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
170318s2016 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2016.Ha.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hala Ashraf Hosni Abdelaziz |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Association of protein tyrosine phosphatase N22 (1858C/T) polymorphism with systemic lupus erythematosus in Egyptian children / |
| Statement of responsibility, etc. |
Hala Ashraf Hosni Abdelaziz ; Supervised Heba Allah M. E. Sharaf Eldin , Azza A. K. Elhamshary , Hany A. F. Elghobary |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
العلاقة بين الاشكال المتعددة فى جين بى تى بى إن 22 سى 1858 تى فى حالات الذئبة الحمراء فى الاطفال المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Hala Ashraf Hosni Abdelaziz , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
122 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, characterized by the production of multiple autoantibodies, complement activation, and immune-complex deposition, resulting in tissue and organ damage. To assess the frequency and possible association of protein tyrosine phosphatase N22 c.C1858T SNP polymorphism with SLE in Egyptian children. Seventy five SLE children patients and Seventy five healthy subjects were tested for PTPN22 (C1858T) genotypes by TaqMan real time PCR, and routine laboratory data (CBC, urea, creatinine) were done. In this study, there was significant difference in PTPN22 rs2476601p.R620W (c.C1858T) genotypes and alleles frequency among cases and the control group. The frequency of CT genotype was higher in SLE cases 5/75 (6.7%) as compared to the control group 0/75 (0.0%) which is statistical significant (P=0.023).The TT genotype was absent in both cases and the control group. Regarding the risky mutant T allele frequency, it was found that T allele frequency was significantly increased in cases 5/150 (3.3%) than the control group 0/150 (0%) (p=0.024). Regarding clinical manifestations, it was found that 4/5 (80%) of patients with CT genotype had renal affection and 20/70(28.57%) with CC genotype had renal affection which is statistically significant (P=0.017), but there was no significant difference between PTPN22 CC and CT genotypes regarding other clinical manifestations |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
c.C1858T |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
PTPN22 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
SLE |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Azza Abdelkadr Elhamshary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hany Ahmed Fouad Elghobary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Heba Allah Mohamed Ebrahim Sharaf Eldin , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
