MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02767cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
170325s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2016.Ek.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ekhlass Talaat Mohammed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Detection of interleukin-2 gene polymorphisms in Egyptian Non-hodgkin lymphoma patients / |
| Statement of responsibility, etc. |
Ekhlass Talaat Mohammed ; Supervised Somaia Abdelrahman Mousa , Manal Mohamed Makhlouf , Hamdi Mohamed Zawam |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة التعدد الشكلى لجين الأنترلوكن - 2 فى المرضى المصريين المصابين بسرطان الغدد الليمفاوية الغير هودجكين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ekhlass Talaat Mohammed , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
197 P. : |
| Other physical details |
facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Interleukin 2 (IL-2) plays a central role in the activation of T cell-mediated immune responses and amplification of the lymphocyte responses in vivo. It promotes natural killer (NK) cell expansion and enhances intrinsic NK cell cytotoxicity. Two polymorphisms, -330T/G and+114T/G, have been identified in the IL-2 gene and are associated with various diseases and cancers. The aim of the study is to study the expression and to assess the impact of genetic polymorphisms of IL-2 on the susceptibility and prognosis of non-Hodgkin's lymphoma (NHL). Sixty patients with NHL as well as 60 age and sex matched healthy control subjects are included in this study. IL-2-330 T/G and+114 T/G genotypes were determined by PCR-RFLP. Our study revealed that both IL-2-330 T/G and+114 T/G gene polymorphisms are associated with increased risk of developing NHL with OR=3.609 (95% CI=1.527-8.417) and 4.142 (95% CI=1.637-10.538) respectively. Also, they increase the risk of bad outcome with OR=17.300 (95% CI=3.392-87.725) and 10.424 (95% CI=1.870-58.413) respectively. Moreover, combined presence of both polymorphisms is associated with about 6 folds increased risk of developing NHL. In conclusion, IL-2-330 T/G and +114 T/G gene polymorphisms could be involved in the pathophysiology and development of NHL. They may be useful as predictive molecular markers for prognosis and disease outcome in NHL patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IL-2-330 T/G |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IL-2+114 T/G |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Non-hodgkin lymphoma |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hamdi Mohamed Zawam , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Mohamed Makhlouf , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Somaia Abdelrahman Mousa , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
