The effect of Ü1-antitrypsin deficiency and bacterial loads on the efficacy of chronic obstructive pulmonary disease pharmacotherapy in Egyptian patients / (Record no. 60437)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03191cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031708.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170327s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2016.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Gamal Ahmed Ahmed Elhennawy |
| 245 14 - TITLE STATEMENT | |
| Title | The effect of Ü1-antitrypsin deficiency and bacterial loads on the efficacy of chronic obstructive pulmonary disease pharmacotherapy in Egyptian patients / |
| Statement of responsibility, etc. | Marwa Gamal Ahmed Elhennawy ; Supervised Yosri Akl , Nirmeen A. Sabry , Ahmed Sherif Attia |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | انتيتريبسين و الاحمال الجرثومية على فعالية المعالجة الدوائية لمرض الانسداد الرئوى المزمن فى المرضى المصريين {u٢١٦٠}Ü تأثير نقص |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Gamal Ahmed Ahmed Elhennawy , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Chronic obstructive pulmonary disease (COPD) is associated with slowly progressive airflow obstruction. Chronic obstructive pulmonary disease (COPD) is caused by the combination of smoking, genetic susceptibility and exacerbated by infection. The genetic cause of COPD is {uF061}1-antitrypsin (AAT) deficiency where the gene encoding this protein shows genetic polymorphisms increasing the complexity of COPD predisposing factors. In addition, the development of pulmonary infections with different bacterial species is associated with exacerbation of COPD. How the different genotypes when combined with different types and loads of bacterial infections could affect the outcome of COPD and its responsiveness to therapy remain unclear. This is especially true regarding Egyptian patients where COPD is widespread and at the same time genotyping of these patients is almost absent. Screen for the AAT deficiency alleles phenotypically and genotypically and hence assess the contribution of two of the most common deficiencies (Pi*S and Pi*Z) and two of the rare deficiencies alleles that were predicted to be prevalent in Egypt (Pi*Mmalton and Pi*Q0Cairo) in the development of COPD in Egypt. Compare this study results to the results collected in North African countries to study the mutation pattern in North Africa. Determine the effects of AATD on the efficacy of COPD conventional pharmacotherapy. Fifty-nine subjects (29 controls and 30 COPD patients) were tested for genetic AATD and respiratory function. The bacterial loads were determined to the patients{u2019} group who were then given a long acting beta-agonist and corticosteroid inhaler for 6 months |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AAT deficiency |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bacteria |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chronic obstructive pulmonary disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Sherif Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nirmeen Ahmed Sabry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yosri Akl , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2016.Ma.E | 01010110071381000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2016.Ma.E | 01020110071381000 | 22.09.2023 | CD - Rom | 71381.CD |