Possible modulative effects of a 5-HT3 antagonist on type 2 diabetes in rats / (Record no. 60631)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02739cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031715.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170411s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2016.Re.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Ali Mohamed Ali Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Possible modulative effects of a 5-HT3 antagonist on type 2 diabetes in rats / |
| Statement of responsibility, etc. | Reem Ali Mohamed Ali Ahmed ; Supervised Hanan S. Elabhar , Omneya Galal |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Ali Mohamed Ali Ahmed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 180 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | T2DM is a multi-pathological disease that entails several organs, including skeletal muscle and brain. Serotonin (5-HT), synthesized within Ý-cells, stored and co-secreted with insulin, raising the curiosity regarding its possible role in diabetes. Hence, the aim of this study was to assess the possible modulatory effects of Tropisetron (Trop), a 5-HT3 receptor antagonist, on T2DM in rats. Animals were allocated into normal and diabetic rats. Diabetic rats were treated with Metformin (500 mg/kg, p.o; Met.), Tropisetron (1 and 2 mg/kg, i.p; Trop1 & 2), or combination of Met. with Trop1. In serum, all treatment regimens, especially Trop1, improved glucose/lipid homeostasis (glucose, fructosamine, insulin, TGs, TC, FFAs). Trop1 and its combination decreased serum RAGE level and increased 5-HT; however, Trop1&2 and Met increased hippocampal 5- HT and insulin. The Trop-mediated improvement in muscular (Phosphorylated insulin receptor substrate 1; pIRS1, protein kinase B; AKT and Glucose transporter 4; GLUT4) and hippocampal (AKT, GLUT4) insulin signaling pathway may be partially responsible for the overall corrected picture. Additionally, muscular/hippocampal contents of Ý-catenin and NF-mB were decreased in Trop1&2 treated rats, pointing for the possible role of Wnt pathway in the Trop. action. In conclusion the study provided evidence for the role of Tropisetron on T2DM, via modulating theinsulin signaling cascade (insulin, pIRS1, AKT, GLUT4), improving lipid/glucose profile, decreasing inflammatory markers (RAGE, NF-mB), as well as increasing serotonin, and reducing Ý-catenin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metformin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tropisetron |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 2 diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan S. Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shaima |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2016.Re.P | 01010110071509000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2016.Re.P | 01020110071509000 | 22.09.2023 | CD - Rom | 71509.CD |