Effect of apelin on obesity- associated type2 diabetes mellitus in male albino rats. possible interaction between APELIN/APJ system, renin angiotensin system and nitric oxide / (Record no. 60691)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03688cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031717.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170419s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2016.Mo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mona Mohamed Ahmed Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of apelin on obesity- associated type2 diabetes mellitus in male albino rats. possible interaction between APELIN/APJ system, renin angiotensin system and nitric oxide / |
| Statement of responsibility, etc. | Mona Mohamed Ahmed Ahmed ; Supervised Maha Mohamed Sabry , Manal Moustafa Mahmoud , Heba Samy Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الأبيلين على مرض السكرى من النوع الثانى المصاحب للسمنه فى ذكور الفئران البيضاء واحتمال تفاعل بين نظام الأبيلين ونظام الرينين /انجوتنسين و أكسيد النيتريك |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mona Mohamed Ahmed Ahmed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 191 p. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Apelin, a recently identified adipokine, and its receptor (APJ) are involved in the regulation of a variety of pathphysiological processes. APJ shares marked sequence homology with angiotensin II type 1 receptor (ATR1) and both receptors are expressed in many different tissues. Objective: the purpose of the present study is to evaluate the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and the possible interaction between apelin/APJ system and renin angiotensin system (RAS) with a particular focus on their relation with endothelial nitric oxide synthase (eNOS) pathway. Methods: forty male albino rats were divided in to 2 groups. Control group (n=8) and diabetic group (n=32). Diabetic group were further subdivided in to four groups; control diabetic group (n=8), apelin treated diabetic group (n=8), apelin+losartan treated diabetic group (n=8), apelin+L-NAME treated diabetic group (n=8). Rats in diabetic group were fed high fat high sucrose (HF-HS) diet for six weeks to induce obesity and insulin resistance (IR) + single low dose of streptozotocin (STZ, 35 mg/kg) at the end of fifth week to induce T2DM. Drugs were given from the start and continued for one week after STZ injection. Apelin-13 was given intraperitoneal (0.1omol/kg /day). Losrtan, angiotensin II type 1 receptor blocker, was given orally (30 mg/kg/day). L-NG-nitroarginine methyl ester (L-NAME), non specific eNOS inhibitor, was given intraperitoneal (10 mg/kg/day). At the end of the study body mass index (BMI) was calculated and blood samples were taken to measure serum Glucose, Insulin, Lipid profile {cholesterol, Triglycerides (TGs), High density lipoprotein (HDL), inflammatory marker: Tumor necrosis factor-Ü (TNFÜ), oxidative stress marker: Malondialdehyde (MDA), endothelial dysfunction marker: Tissue plasminogen activator (T-PA) antigen, and Nitric oxide (NO) levels. After decapitation, adipose tissue was taken for the determination of gene expression of (ATR1) and angiotensin converting enzyme 2 (ACE2) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Angiotensin system (RAS) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apelin, Renin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 2 Diabetes Mellitus (T2DM) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Samy Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Mohamed Sabry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal Moustafa Mahmoud , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shaima |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2016.Mo.E | 01010110071523000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2016.Mo.E | 01020110071523000 | 22.09.2023 | CD - Rom | 71523.CD |