Circulating micro-RNAs as non-invasive molecular biomarkers for early detection breast cancer / (Record no. 60721)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03179cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031718.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170429s2016 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.M.Sc.2016.Es.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Esraa Aly Zeen Elabdeen Khalil Elaidy |
| 245 10 - TITLE STATEMENT | |
| Title | Circulating micro-RNAs as non-invasive molecular biomarkers for early detection breast cancer / |
| Statement of responsibility, etc. | Esraa Aly Zeen Elabdeen Khalil Elaidy ; Supervised Mohammed Aly Eldesouky , Ibrahim Abdelsalam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الحمض النووى الريبونيوكليكى الدقيق الدوار كدلالات بيولوجيه جزيئيه غير مجتاحه للكشف المبكر عن سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Esraa Aly Zeen Elabdeen Khalil Elaidy , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 102 P. : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Breast cancer (BC) is the second most common cancer in the world and, the most frequent cancer among women with an estimated 1.67 million new cancer cases diagnosed worldwide during 2012 which represents 25% of all cancers. In Egypt, breast cancer is the most common cancer among women. One of the major BC risk factors is the family history of the disease. Women with positive BC family history were three times more likely to get the disease. MiRNAs are short, non-protein-coding RNAs {u223C}22 nucleotides in length that are known to alter gene expression at a post-transciptional level. In recent years, circulating miRNAs have attracted a great deal of attention as promising novel markers for various diseases. Here, we investigated their potential to serve as minimally invasive, early detection markers for breast cancer in blood plasma. We profiled miRNAs extracted from the plasma of early stage breast cancer patients (taken at the time-point of diagnosis) and 23 familial high risk individuals as well as healthy control individuals using syber green RT-qPCR. one miRNA (miR-21) was shown to be significantly upregulated While miR-let 7c shown to be significantly down regulated in the plasma of early stages breast cancer patients. On the other hand, both of miR-21 and miR-148b had significant differences between early stages breast cancer patients and familial high risk individuals. In conclusion, the identified miRNAs might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer. Such a multimarker blood test might for instance provide a prescreening tool, especially for younger women, to facilitate decisions about which individuals to recommend for further diagnostic tests |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Circulating miRNAs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Familial high risk individuals |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ibrahim Abdelsalam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Aly Eldesouky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.M.Sc.2016.Es.C | 01010110071588000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.M.Sc.2016.Es.C | 01020110071588000 | 22.09.2023 | CD - Rom | 71588.CD |