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Clinical significance of Neutrophil gelatinase-associated lipocalin and Matrix metalloproteinase-9 in colorectal cancer / (Record no. 60796)

MARC details
000 -LEADER
fixed length control field 04377cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223031720.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170506s2016 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level M.Sc
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.12.02.M.Sc.2016.Mo.C
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Mona Elsayed Badr Elsayed
245 10 - TITLE STATEMENT
Title Clinical significance of Neutrophil gelatinase-associated lipocalin and Matrix metalloproteinase-9 in colorectal cancer /
Statement of responsibility, etc. Mona Elsayed Badr Elsayed ; Supervised Mervat Elsayed Mohammed , Mohamed Ali Eldesouky , Mohammed Diaa Eldeen Abdelmaksoud
246 15 - VARYING FORM OF TITLE
Title proper/short title ا{uئإئ٧}ھ{ێښڙڙڈ̆{ێښږښښ̆{ێښڙڍڈ ̆ا{uئإؤئ}{uئإأأ}{uئإئأ}{uئإ٩ئ}{uئآئئ}{uئإ٩٤} {uئإؤئ}{uئإإ٠}{uئإإ٠}{uئآئئ}{uئإ٩٢}{uئإإإ}{uئإؤآ}{uئإ٨إ}{uئإؤئ}{uئآئئ}{uئإإ٦} ا{uئإؤئ}{uئإإ٤}{uئإءإ}{uئإ٩٧}{uئإ٩٢}{uئإأ٢} {uئإ٩١}{uئإ٨إ}{uئإؤئ}{uئإإ٨}{uئآئئ}{uئإ٩٨}{uئإءإ}و{uئإؤ٣}{uئآئئ}{uئإؤإ} {uئإ٩ئ}{uئآئئ}{uئإئأ}{uئإ٩٧}{uئآئئ}{uئإإ٨}{uئآئئ}{uئإآ٠} و ا{uئإؤئ}{uئإإ٤}{uئإ٨إ}{uئإ٩٧}{uئإءإ}{uئآئإ}{uئإؤأ}{uئإآ٢} {uئإإ٣}{uئآئئ}{uئإ٩٨}{uئإ٨إ}{uئإؤئ}{uئإإإ}{uئإ٩١}{uئإءإ}و{uئإ٩٧}{uئآئئ}{uئإإ٨}{uئآئئ}{uئإآ٠} -٩ {uئإؤ٣}{uئإئ٠} {uئإآ٣}{uئإءإ}ط{uئإ٨إ}ن ا{uئإؤئ}{uئإؤ٨}{uئإإإ}{uئإؤئ}{uئإإإ}ن ا{uئإؤئ}{uئإإ٤}{uئإآ٤}{uئإ٩٨}{uئإؤ٨}{uئآئئ}{uئإإ٤}{uئإئ٠}
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Mona Elsayed Badr Elsayed ,
Date of publication, distribution, etc. 2016
300 ## - PHYSICAL DESCRIPTION
Extent 126 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520 ## - SUMMARY, ETC.
Summary, etc. Purposes: Neutrophil gelatinase-associated lipocalin (NGAL), a recently recognized protein that binds to Matrix metalloproteinase-9 (MMP9).There is growing evidence implicating that Neutrophil gelatinase{u2013}associated lipocalin and Matrix metalloproteinase-9 play a role in the development and progression of cancers. In this study, we investigated the role of NGAL and MMP-9 in the tumorigenesis and progression of Colorectal Cancer (CRC).We showed the correlation between the plasma levels of NGAL and MMP-9 in CRC, and also we studied the effect of treatment with chemotherapy and/or radiotherapy on plasma levels of NGAL and MMP-9 in human CRC. Methods: We used ELISA immunoassay to measure the levels of plasma NGAL and MMP-9 in a cohort consisting of colorectal cancer patients (n=50) and controls (n=30). Cases were assigned into 5 groups: Group 1(Control),Group 2 (Patients with early stages (I,II), who weren{u2019}t receive chemotherapy and /or radiotherapy), Group 3 (Patients with early stages (I,II), who were received chemotherapy and/ or radiotherapy, Group 4 (Patients with late stages (III, IV), who weren't receive chemotherapy and/or radiotherapy) and Group 5(Patients with late stages (III, IV), who were received chemotherapy and/ or radiotherapy).Results: Both NGAL and MMP-9 plasma levels were highly significantly elevated in all studied groups compared to control group (P<0.0001) but no significant differences in plasma levels of NGAL and MMP-9 were found between groups that received treatment with chemotherapy and /or radiotherapy and those not received, or between different stages (Tumor Nodes Metastases staging (TNM)) of CRC. In addition we found significant correlation between levels of NGAL and levels of MMP-9(P = 0.044). NGAL was positively correlated with MMP-9 (The correlation coefficient between NGAL and MMP-9 was 0.286).Conclusion: Our study suggested that NGAL and MMP-9 may be have screening role but not for prognosis of CRC Patients and they have no value in monitoring the effect of treatment with chemotherapy and/or radiotherapy on CRC patients
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Colorectal cancer
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term MMP-9
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term NGAL
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mervat Elsayed Mohammed ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mohamed Ali Eldesouky ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mohammed Diaa Eldeen Abdelmaksoud ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Enas
Reviser Cataloger
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.12.02.M.Sc.2016.Mo.C 01010110070946000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.12.02.M.Sc.2016.Mo.C 01020110070946000 22.09.2023 CD - Rom 70946.CD