Association between gene polymorphism of IL13/IL-RÜ signaling pathway and severity of bronchial asthma / (Record no. 61019)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02750cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031726.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170529s2016 ua a f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2016.Ma.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Fathi Abdallah |
| 245 10 - TITLE STATEMENT | |
| Title | Association between gene polymorphism of IL13/IL-RÜ signaling pathway and severity of bronchial asthma / |
| Statement of responsibility, etc. | Marwa Fathi Abdallah ; Supervised Samia Mostafa Mohammed , Eman Obaia , Nabila Ebrahim Laz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | علاقة تعدد اشكال جينات الطريق الاشارى (الانترلوكن 13- مستقبل الفا للا نترلوكن 4) و شدة مرض الربو الشعبى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Fathi Abdallah , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 143P. : |
| Other physical details | ill. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Different genes are associated with categorical classifications of asthma severity. However, continuous outcomes should be used to catch the heterogeneity of asthma phenotypes and to increase the power in association studies. The aim of our work is to investigate whether there is association between single nucleotide polymorphism (SNPs) in 3 candidate genes of IL-13/IL-4RÜ signaling pathway and the severity of bronchial asthma. Sixty subjects were enrolled in this study divided into 3 main groups: healthy control group (20 subjects), patients with severe bronchial asthma (20 subjects) and patients with mild bronchial asthma (20 subjects). Each group is subdivided into smokers and non smokers. IL-13 C1923T, IL-4 C-590T and IL-4 RA 175V were assessed using restriction fragment length polymorphism (RFLP). Results revealed that polymorphism of IL-13 C1923T genotypes and T allele as well as polymorphism of IL-4 R 175V genotypes and G allele are correlated to severity of asthma on one hand and with smoking status of patients on the other hand. These data suggest that genetic variants in IL-13/IL-4RÜ signaling pathway may be involved in the development of severe asthma. In addition, a new pattern of biological interaction that affects the severity of asthma is described between SNPs of both IL-13 C1923T and IL-4 RA 175V and smoking |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bronchial asthma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-13/IL-4 signaling pathway |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymorphism |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Obaia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nabila Ebrahim Laz , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Mostafa Mohammed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.A | 01010110071753000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.A | 01020110071753000 | 22.09.2023 | CD - Rom | 71753.CD |