Nanocarriers for enhancement of bioavailability of an antihypertensive drug / (Record no. 61192)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02768cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031732.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170613s2016 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2016.Ly.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lydia Adel Labib Hanna |
| 245 10 - TITLE STATEMENT | |
| Title | Nanocarriers for enhancement of bioavailability of an antihypertensive drug / |
| Statement of responsibility, etc. | Lydia Adel Labib Hanna ; Supervised Omaima Naim Elgazayerly , Emad B. Basalious |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | استخدام الحوامل متناهيه الصغر لتحسين الاتاحه الحيويه لعقار خافض لضعط الدم العالى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Lydia Adel Labib Hanna , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 215 P. : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Optimized drug administration allows the delivery of the drug to the correct location and provides an effective concentration for the required length of time, thereby achieving the therapeutic objective with minimal side effects. The challenge lies in manipulating the formulation to produce a release rate which is appropriate for the pharmacokinetic properties of the drug; resulting in a concentration-time profile at the site of action that will meet the pharmacological requirements. This must be fulfilled in a product that will be readily accepted by the patient, otherwise non-compliance will result in drug delivery failure. Bosentan is a drug belonging to endothelin receptor antagonist (ERA) that can be used for pulmonary arterial hypertension. It is available in two concentrations 62.5 mg and 125 mg twice daily. Bosentan is a poorly water soluble drug. The oral delivery of bosentan suffers from several drawbacks such as low bioavailability (absolute bioavailability 50%), short duration of action necessitating frequent administration and systemic hypotension. The main side effects include headache, flushing and increased liver enzymes. Pulmonary administration would circumvent the pre-systemic hepatic metabolism thus improving the bioavailability of bosentan. Moreover, the direct delivery to the lung avoids the systemic adverse effects of oral ERA. However, the short duration of action and the frequent administration are the major drawbacks of inhalation therapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antihypertensive drug |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Enhancement |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanocarriers |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad B. Basalious , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omaima Naim Elgazayerly , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2016.Ly.N | 01010110071830000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2016.Ly.N | 01020110071830000 | 22.09.2023 | CD - Rom | 71830.CD |