MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03519cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
170619s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.04.M.Sc.2016.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marwa Sobhy Ahmed Hassan |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis of cinnoline derivatives as anticancer agents / |
| Statement of responsibility, etc. |
Marwa Sobhy Ahmed Hassan ; Supervisied Manal Mostafa Kandeel , Aliaa Mohamed Kamal , Bassem Heshmat Naguib |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشيييد مشتقات الينولين كمضادات للاورام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Marwa Sobhy Ahmed Hassan , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
123 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University -Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The present thesis comprises four chapters. The first chapter is an introduction which is composed of two parts. The first part is a brief literature survey on the synthesis of cinnoline, pyrimidocinnoline and triazepinocinnoline derivatives. The second part is a survey covering topoisomerase I inhibitors as one of the recent fields of research, some reported cinnoline derivatives with anticancer activity and mechanisms of anticancer activity of some reported cinnoline derivatives. The second chapter demonstrates the aim of the work, along with the Schemes that had been carried out to obtain new cinnoline derivatives. The third chapter explains the theoretical discussion of the experimental work used for the preparation of the newly synthesized compounds, together with explanation of their spectroscopic data. Scheme of starting materials, reveals the preparation of the root compounds viz. 4-amino-6-substituted cinnoline-3-carboxamides (IIa,b), 4- amino-6-substituted cinnoline-3-carbohydrazides (Va,b) and their corresponding acids IIIa,b and esters IVa,b are presented. Scheme 1, compounds IIa,b were refluxed with acetic anhydride to yield pyrimidocinnoline derivatives VIa,b. However, the reaction of IIa,b with certain phenacyl bromides gave 4-(2-aryl-2-oxoethylamino)-6-substituted cinnoline-3- carboxamides (VIIa-g) rather than diazepinocinnolines A. Scheme 2, cyclization of the hydrazides Va,b with acetic acid gave triazepinocinnoline derivatives VIIIa,b. On the other hand, reacting Vb with different aromatic acids gave unexpectedly triazepinocinnoline derivatives IXa,b instead of the oxadiazolylcinnoline derivatives B. Moreover, heating Vb with the appropriate aromatic aldehyde yielded the corresponding arylidene derivatives Abstract vii Xa-d. Cyclization of the latter Xa with acetic anhydride gave unexpectedly pyrimidocinnoline derivative XI instead of oxadiazolylcinnoline derivative C. Scheme 3, cyclization of the hydrazide Vb with carbon disulphide yielded the triazepinocinnoline derivative XII instead of the expected pyrimidocinnoline derivative XIII. However, triazepinocinnoline derivative XII underwent thermal isomerization upon refluxing with xylene (high boiling point solvent) to give the more thermodynamically stable pyrimidocinnoline derivative XIII |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cinnolines |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrimidocinnolines |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Triazepinocinnolines |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aliaa Mohamed Kama , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bassem Heshmat Naguib , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Mostafa Kandeel , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
