The association of interferon-Þ and interleukin-8 gene polymorphisms with oral lichen planus in Egyptian hepatitis C patients / (Record no. 61530)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03486cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031742.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170712s2016 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.05.M.Sc.2016.No.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Adel Ibrahim Eldessouki Azab |
| 245 14 - TITLE STATEMENT | |
| Title | The association of interferon-Þ and interleukin-8 gene polymorphisms with oral lichen planus in Egyptian hepatitis C patients / |
| Statement of responsibility, etc. | Noha Adel Ibrahim Eldessouki Azab ; Supervised Shahira Gamal Eldin Elashiry , Enji Ahmed Mahmoud , Marwa Elsharkawy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الكشف عن العلاقة بين تعدد الشكل الجينى لانترفيرون جاما و انترلوكين-8 و مرض الحزاز الفموى المنبسط فى مرضى فيروس الكبد الوبائى سى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Adel Ibrahim Eldessouki Azab , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 129 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral - Radiology and Diagnosis |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Lichen planus (LP) is a chronic inflammatory disease that affects skin and mucous membranes of squamous cell origin. LP probably represents a cell-mediated immunologic response to an induced antigenic change in the skin or mucosa. The etiology of OLP is unclear in most instances, however HCV may be implicated. Numerous studies have suggested that cytokine gene polymorphisms may influence the outcome of HCV-infected OLP patients. Interferon-gamma (IFN-{u0264}) is a T-helper1 cytokine involved in the activation of cellular immunity. This cytokine maintains the expression of major histocompatibility (MHC) class II by keratinocytes, thereby contributing to disease onset and chronicity of OLP. IL-8 gene has been associated with the susceptibility of individuals to OLP, as well as the progression and prognosis of this disease. The aim of this study was to investigate the presence of SNPs rs4073 and rs2430561 in IL-8 and IFN-Þ genes respectively and investigate their association with HCV-related OLP and to disease severity. The present study included 60 subjects, divided into four groups of 15. The groups were as follows: OLP patients positive for HCV infection, OLP patients with no HCV infection, HCV patients with no oral lesions and subjects with no HCV infection no oral lesions. Analysis was done using real-time PCR, and consequent melting curve analysis was performed on LightCycler® 2.0 Instruments for identification of polymorphisms in -251 A/T (rs4073) in the promoter region of IL-8 gene and +874 T/A (rs2430561) in exon 1 in IFN-{u0264} gene. This study found that HCV infection can act as an aggravating factor for OLP, making those patients 11 times more prone to develop erosive type of OLP. IFN-Þ rs2430561 T>A genotype frequencies showed no difference between cases and controls. As for IL-8 rs4073 A>T, there was no significant difference in genotype and frequency among the 4 studied groups |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | INF-Þ |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lichen planus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Enji Ahmed Mahmoud , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Elsharkawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Gamal Eldin Elashiry , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.05.M.Sc.2016.No.A | 01010110072088000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.05.M.Sc.2016.No.A | 01020110072088000 | 22.09.2023 | CD - Rom | 72088.CD |