Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents / (Record no. 61839)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01824cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031751.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170807s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Gift |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.34.M.Sc.2015.Ah.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Kamal Mohammed Elhady |
| 245 10 - TITLE STATEMENT | |
| Title | Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents / |
| Statement of responsibility, etc. | Ahmed Kamal Mohammed Elhady ; Supervised Ashraf H. Abadi , Nazih Noureldin , Nermin Salah |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Kamal Mohammed Elhady , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 Leaves : |
| Other physical details | charts ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | PDE5 enzyme is expressed in various parts of the human body, and thus PDE5 inhibitors has as PDE5 inhibitors for the treatment of MED and PAH, one of the most potent orreversble inhibitors of PDE5 enzyme currently present in the market it tadalafil; tadalafil is chemically classified as a tetrahydro-Ý- carboline-based PDE5 inhibitors. Recent studies showed that PDE5 and other PDEs are over-expressed in malignant tumors, thus inibiting these PDEs and the consequent rise of cGMP levels can lead to apoptosis and anticancer activities. |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hydrophlilc side chain |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Novel tetrahydrobeta-carbolines |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Potential phosphdiesterase 5 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashraf H. Abadi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nazih Noureldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nermin Salah , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الثقاقات الاجنبية - الدور الثالث | 11.02.2024 | Cai01.34.M.Sc.2015.Ah.D | 01010110072199000 | 05.07.2024 | Thesis |