Study of the possible effect of pyrrolidine dithiocarbamate and hesperidin on experimentally induced pulmonary fibrosis / (Record no. 62119)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03159cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031800.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170823s2017 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2017.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mai Amin Kamel Zaafan |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible effect of pyrrolidine dithiocarbamate and hesperidin on experimentally induced pulmonary fibrosis / |
| Statement of responsibility, etc. | Mai Amin Kamel Zaafan ; Supervised Sanaa A. Kenawy , Amany I. Elbrairy , Hala F. Zaki |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير المحتمل لبيروليدين داى ثيو كاربامات و هسبيردين فى التليف الرئوى المحدث تجريبيا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mai Amin Kamel Zaafan , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 121 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pulmonary fibrosis is a chronic progressive and ultimately fatal lung disease. It is characterized by epithelial cell apoptosis, fibroblast proliferation and abnormal accumulation of extracellular matrix molecules, particularly collagen. Objective: The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100 mg/kg) and hesperidin (200 mg/kg) on bleomycin-induced pulmonary fibrosis (5 mg/kg; intratracheal) in rats. Materials and methods: Rats were randomly assigned to three groups: normal control, bleomycin control, PDTC-treated and hesperidin-treated groups. Lung injury was evaluated through histological examination, immunohistochemical detection of inducible nitric oxide synthase (iNOS) in lung tissue and evaluating the total and differential leucocytes count in bronchoalveolar lavage fluid. Lung tissue was used for biochemical assessment of lung content of hydroxyproline, transforming growth factor beta-1 (TGF-Ý1), tumor necrosis factor-alpha (TNF-Ü) as well as analysis of lipid peroxides, reduced glutathione (GSH), and total nitrite contents. Results: PDTC and hesperidin attenuated bleomycin-induced pulmonary fibrosis as evidenced by histological observations, decreased iNOS expression and prevention of bleomycin-induced altered total and differential leukocytes count. Additionally, PDTC and hesperidin caused a significant decrease in lung contents of hydroxyproline, TGF-Ý1, TNF-Ü, lipid peroxides, and total nitrite coupled with increase in lung GSH content as compared to bleomycin control group. Conclusion: PDTC and hesperidin attenuated bleomycin-induced pulmonary fibrosis in rats via its anti-inflammatory, antioxidant, and antifibrotic activities |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hesperidin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pulmonary fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrrolidinedithiocarbamate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Ibrahim Elbrairy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelbaky Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2017.Ma.S | 01010110072561000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2017.Ma.S | 01020110072561000 | 22.09.2023 | CD - Rom | 72561.CD |