Possible role of stem cells and-or some tyrosine kinase inhibitors in the treatment of lipopolysaccharide-induced liver injury in rats / (Record no. 62276)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02844cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031804.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170912s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2016.Om.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omnia Shafik Zaki |
| 245 10 - TITLE STATEMENT | |
| Title | Possible role of stem cells and-or some tyrosine kinase inhibitors in the treatment of lipopolysaccharide-induced liver injury in rats / |
| Statement of responsibility, etc. | Omnia Shafik Zaki ; Supervised Afaf A. Ain-Shoka , Laila A. Rashed , Marwa M. Safar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المحتمل للخلايا الجذعية و- أو بعض مثبطات تيروزين كينيز في علاج إصابة الكبد المحدثة بالليبوبولي سكاريد في الجزذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omnia Shafik Zaki , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 177 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sepsis caused by lipopolysaccharide (LPS) is a life-threatening disease accompanied by multiple organ failure. This study investigated the curative effects of N-acetylcysteine (NAC), bone marrow derived mesenchymal stem cells (BM-MSCs), or imatinib (IMA) against hepatic, renal and pulmonary responses caused by single administration of LPS (10 mg/kg, i.p) in rats. Treatment with BM-MSCs (5{u00D7}105 in 0.1 ml PBS, i.p.) 3 hours after LPS, or IMA (15 mg/kg, i.p.) 30 minutes after LPS antagonized the LPS-induced elevation of the liver enzymes (ALT, AST), kidney functions (BUN, sCr) as well as the increased lung pulmonary vascular permeability and pulmonary edema. Both BM-MSCs and IMA decreased tissues{u2019} contents of the TNF-Ü, NF-mB, IL-1Ý, iNOS, P38-MAPK, STAT-3, Bax. They also increased the anti-inflammatory cytokine IL-10 and the anti-apoptotic mediator Bcl-2. Meanwhile, rats exhibited marked reduction of the broncho-alveolar lavage fluid contents of TNF-Ü, IL-1Ý, IFN-Þ, and neutrophils count. These ameliorative effects were comparable to those produced by NAC (300 mg/kg, p.o) given once directly after LPS. Notably, BM-MSCs exerted anti-inflammatory, anti-oxidant as well as anti-apoptotic potentials to a better extent than IMA. In conclusion, BM-MSCs and IMA can be probably introduced as candidates for the treatment of systemic inflammation caused by LPS. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Endotoxin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Stem Cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Afaf A. Ain-Shoka , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila A. Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa M. Safar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2016.Om.P | 01010110072446000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2016.Om.P | 01020110072446000 | 22.09.2023 | CD - Rom | 72446.CD |