The differentiation potential of human cord blood- derived mesenchymal stem cells into functional hepatocyte-like cells on nanofibrous scaffold / (Record no. 62302)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03158cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031805.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170912s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2016.Di.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dina Samir Abdelhady |
| 245 14 - TITLE STATEMENT | |
| Title | The differentiation potential of human cord blood- derived mesenchymal stem cells into functional hepatocyte-like cells on nanofibrous scaffold / |
| Statement of responsibility, etc. | Dina Samir Abdelhady ; Supervised Taghreed Mohamed Gaafar , Zeinab Abou Bakr Demerdash , Nermine Magdi Riad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | قدرة الخلايا الجذعية الميزنشية المستخلصة من دم الحبل السري المزروعة علي انسجة النانو (سمافولد) علي التمايز الي خلايا كبدية فعالة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dina Samir Abdelhady , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 204 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Mesenchymal stem cell (MSC) based liver tissue engineering on nano-fibrous scaffold holds great promise for cell-based therapy in end- stage liver failure. Scaffolds are three-dimensional (3D) matrices that provide the initial structural support for cells to attach, proliferate, and differentiate, facilitating the formation of an extracellular matrix (ECM). Aim of the Work: In this study we examined the differentiation potential of MSCs into hepatocytes in two- and three-dimensional (2D and 3D) culture systems to improve the in vitro-hepatic differentiation of MSCs to be used in tissue-based therapies in patients with chronic liver diseases. Materials and Methods: MSCs were isolated from human umbilical cord blood (UCB). Hepatogenic differentiation was induced on 2D and 3D culture system and hepatogenic function was evaluated by immunocytochemistry, Periodic acid Schiff staining (PAS), enzyme linked immunosorbent assay (ELISA), and gene expression analysis. Differentiated cells were injected intravenously (IV) into murine model of carbon tetra chloride (CCL4) induced liver fibrosis. Animal models were divided into 3 groups, including pathological control group injected with CCL4, CCL4-induced liver fibrotic group treated with 2D differentiated cells, and CCL4-induced liver fibrotic group treated with 3D differentiated cells. Livers were stained with anti-human alpha-feto protein (AFP) and albumin immunoperoxidase staining. Sera were collected and tested for Alanine transaminase (ALT), aspartate aminotransferase (AST), and albumin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mesenchymal stem cells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mesenchymal stem cells (MSCs) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanofibrous scaffold |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nermine Magdi Riad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taghreed Mohamed Gaafar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Abou Bakr Demerdash , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2016.Di.D | 01010110072456000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2016.Di.D | 01020110072456000 | 22.09.2023 | CD - Rom | 72456.CD |