header

The differentiation potential of human cord blood- derived mesenchymal stem cells into functional hepatocyte-like cells on nanofibrous scaffold / (Record no. 62302)

MARC details
000 -LEADER
fixed length control field 03158cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223031805.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170912s2016 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2016.Di.D
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Dina Samir Abdelhady
245 14 - TITLE STATEMENT
Title The differentiation potential of human cord blood- derived mesenchymal stem cells into functional hepatocyte-like cells on nanofibrous scaffold /
Statement of responsibility, etc. Dina Samir Abdelhady ; Supervised Taghreed Mohamed Gaafar , Zeinab Abou Bakr Demerdash , Nermine Magdi Riad
246 15 - VARYING FORM OF TITLE
Title proper/short title قدرة الخلايا الجذعية الميزنشية المستخلصة من دم الحبل السري المزروعة علي انسجة النانو (سمافولد) علي التمايز الي خلايا كبدية فعالة
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Dina Samir Abdelhady ,
Date of publication, distribution, etc. 2016
300 ## - PHYSICAL DESCRIPTION
Extent 204 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Background: Mesenchymal stem cell (MSC) based liver tissue engineering on nano-fibrous scaffold holds great promise for cell-based therapy in end- stage liver failure. Scaffolds are three-dimensional (3D) matrices that provide the initial structural support for cells to attach, proliferate, and differentiate, facilitating the formation of an extracellular matrix (ECM). Aim of the Work: In this study we examined the differentiation potential of MSCs into hepatocytes in two- and three-dimensional (2D and 3D) culture systems to improve the in vitro-hepatic differentiation of MSCs to be used in tissue-based therapies in patients with chronic liver diseases. Materials and Methods: MSCs were isolated from human umbilical cord blood (UCB). Hepatogenic differentiation was induced on 2D and 3D culture system and hepatogenic function was evaluated by immunocytochemistry, Periodic acid Schiff staining (PAS), enzyme linked immunosorbent assay (ELISA), and gene expression analysis. Differentiated cells were injected intravenously (IV) into murine model of carbon tetra chloride (CCL4) induced liver fibrosis. Animal models were divided into 3 groups, including pathological control group injected with CCL4, CCL4-induced liver fibrotic group treated with 2D differentiated cells, and CCL4-induced liver fibrotic group treated with 3D differentiated cells. Livers were stained with anti-human alpha-feto protein (AFP) and albumin immunoperoxidase staining. Sera were collected and tested for Alanine transaminase (ALT), aspartate aminotransferase (AST), and albumin
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Mesenchymal stem cells
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Mesenchymal stem cells (MSCs)
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Nanofibrous scaffold
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Nermine Magdi Riad ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Taghreed Mohamed Gaafar ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Zeinab Abou Bakr Demerdash ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2016.Di.D 01010110072456000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2016.Di.D 01020110072456000 22.09.2023 CD - Rom 72456.CD