Possible antidiabetic and renoprotective effects of aliskiren and spironolactone in STZ-induced diabetes in rats / (Record no. 62402)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03234cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031809.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170919s2017 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2017.Am.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amal Mohamed Mahfoz Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Possible antidiabetic and renoprotective effects of aliskiren and spironolactone in STZ-induced diabetes in rats / |
| Statement of responsibility, etc. | Amal Mohamed Mahfoz Ahmed ; Supervised Afaf Abdelmonaem Ain Shoka , Hekma Abdeltawab Abdellatif , Nahed Mohamed Ahmed Hassanein |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثييرالمحتمل المضاد للسكرى و الواقى للكلى لأليسكيرين و سبيرونولاكتون فى السكرى المحدث بستربتوزوتوسين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amal Mohamed Mahfoz Ahmed , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 192 Leaves : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diabetic nephropathy (DN) is becoming an ever larger health burden worldwide, more effective therapies are needed. In the present study, the antidiabetic and renoprotective effects of aliskiren a renin inhibitor and spironolactone an aldosterone antagonist were evaluated in streptozotocin (STZ) induced DN in rats. Diabetic nephropathy was induced by a single intraperitoneal injection of STZ (65 mg/kg). After 3 days, rats were divided into 6 groups: normal, diabetic, diabetic rats treated with gliclazide (10 mg/kg/day), diabetic rats treated with aliskiren (50 mg/kg/day), diabetic rats treated with spironolactone (20 mg/kg/day) and diabetic rats treated with combination of aliskiren (25 mg/kg/day) and spironolactone (10 mg/kg/day). After one month of treatment, mean arterial blood pressure and heart rate were recorded. Then rats were euthanized and serum was separated for determination of glucose, insulin, kidney function tests, superoxide dismutase activity (SOD), adiponectin and nitric oxide (NO). Kidneys were isolated, one kidney was used for estimation of malondialdehyde (MDA), reduced glutathione (GSH) and tumor necrosis factor alpha (TNF-Ü), whereas the other kidney was used for histopathological study and immunohistochemical measurement of caspase 3 and transforming growth factor beta (TGF-Ý). In addition, islets of Langerhans were isolated from non-fasting normal rats by collagenase digestion technique. Isolated Ý cells were divided into 11 groups and were treated as follows: normal control, 20 æl (40 omol/L) gliclazide, 20 æl (100 omol/L) aliskiren alone or in combination with gliclazide, 20æl (5æg/L) spironolactone alone or in combination with gliclazide |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aliskiren |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetic nephropathy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Renin angiotensin system |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Afaf Abdelmonaem Ain Shoka , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hekma Abdeltawab Abdellatif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nahed Mohamed Ahmed Hassanein , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2017.Am.P | 01010110072728000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2017.Am.P | 01020110072728000 | 22.09.2023 | CD - Rom | 72728.CD |