Study of the effect of low dose of radiation alone or combined with therapeutic agent (s) in experimentally induced fibromyalgia in rats / (Record no. 62601)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03254cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031815.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170930s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Em.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Eman Elsayed Mohamed Elsayed Shibrya |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the effect of low dose of radiation alone or combined with therapeutic agent (s) in experimentally induced fibromyalgia in rats / |
| Statement of responsibility, etc. | Eman Elsayed Mohamed Elsayed Shibrya ; Supervised Sanaa A. Kenawy , Esmat A. Shaaban , May A. Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير جرعة صغيرة من الإشعاع منفرده أو مجتمعه مع مادة أو مواد علاجية للألم الليفى العضلى المستحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Eman Elsayed Mohamed Elsayed Shibrya , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 115 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Fibromyalgia is a syndrome of diffuse body pain with associations of fatigue, sleep disturbance, cognitive changes, mood disturbance, and other variable somatic symptoms. The present work was constructed to study the potential therapeutic effect of low dose gamma irradiation alone or combined with duloxetine or curcumin on an experimental model of fibromyalgia induced by reserpine in rats. Reserpine was administered subcutaneously once daily for three consecutive days in a dose of 1 mg/kg. Rats were treated by exposure to a single low dose of gamma radiation (0.5Gy) on day 7 of the experiment. Duloxetine (30 mg/ kg, p.o.) was administered on day 8 of the experiment 1 h before behavioural assessment. Curcumin (300 mg/kg, p.o.) was administered once daily for four consecutive days (i.e. day 4, 5, 6 and 7). The immobility time of rats in the forced swimming test was assessed. Moreover, the brain content of biogenic amines (serotonin, dopamine and norepinephrine) as well as brain oxidative stress biomarkers (malondialdehyde, glutathione and nitric oxide) were estimated. Reserpine administration increased the immobility time, decreased the brain biogenic amines and increased brain oxidative stress biomarkers. Treatment of reserpinized rats with Low dose of Þ irradiation (0.5Gy) alone or combined with either duloxetine (30 mg/ kg, p.o.) or curcumin (300 mg/kg, p.o.) resulted in significant reduction in the immobility time, amelioration of brain biogenic amines reduction and improvement of brain oxidant status. On the basis of the presented evidences, it could be concluded that low dose of Þ irradiation alone or combined with either duloxetine or curcumin could be of value in the management of fibromyalgia |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fibromyalgia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Low dose Þ irradiation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Reserpine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Esmat Abdelsalam Shaaban , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | May Ahmed Galal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelbaky Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Em.S | 01010110072863000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Em.S | 01020110072863000 | 22.09.2023 | CD - Rom | 72863.CD |