Understanding the molecular mechanisms involved in the regulation of the immune response to cancer-related inflammation / (Record no. 62603)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02865cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031815.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170930s2017 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.Ph.D.2017.Sa.U |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Safaa Abdelsalam Ezzeldeen Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Understanding the molecular mechanisms involved in the regulation of the immune response to cancer-related inflammation / |
| Statement of responsibility, etc. | Safaa Abdelsalam Ezzeldeen Ibrahim ; Supervised Magdy A. Amin , Kenneth D. Beaman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فهم الآليات الجزيئية المشاركة فى تنظيم الاستجابة المناعية للالتهابات ذات الصلة بالسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Safaa Abdelsalam Ezzeldeen Ibrahim , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 124 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Tumors are characterized by persistent inflammation that have important roles in progression of tumors and survival of cancer patients. Inflammatory immune cells specifically tumor-associated neutrophils (TAN) are considered essential components in the tumor microenvironment. In invasive breast cancer, TAN represent a significant portion of the tumor mass and are associated with increased angiogenesis and metastasis. Identifying the regulatory factors that control TAN behavior will help in developing new and specific therapeutic targets for cancer treatment. Vacuolar ATPases (V-ATPases), multi-subunit proton pumps, are highly expressed in metastatic breast cancer cells. A cleaved peptide from a2 isoform V-ATPase (a2NTD) has immunomodulatory role in tumor microenvironment. In this study, we report for the first time the role of V-ATPase in neutrophils modulation. In invasive breast cancer cells, a2NTD was detected and a2V was highly expressed on the surface. Immunohistochemical analysis in invasive breast cancer tissues revealed that increased neutrophil recruitment and blood vessel density were correlated with increased a2NTD levels. In order to determine the direct regulatory role of a2NTD on neutrophils, recombinant a2NTD was used for the treatment of neutrophils isolated from the peripheral blood of healthy volunteers. Neutrophils treated with a2NTD (a2Neu{u0278}) showed increased secretion of IL-1RA, IL-10, CCL-2 and IL-6 that are important in cancer related inflammation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neutrophils |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vaculoar |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kenneth D. Beaman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy A. Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.Ph.D.2017.Sa.U | 01010110072865000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.Ph.D.2017.Sa.U | 01020110072865000 | 22.09.2023 | CD - Rom | 72865.CD |