High-حerformance system for detecting novel altered regions of Hepatocellular carcinoma using high-throughput sequencing / (Record no. 62688)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02636cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031817.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171002s2017 ua dbh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.13.03.Ph.D.2017.Es.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Esraa Mamdouh Hashim Shabeb |
| 245 10 - TITLE STATEMENT | |
| Title | High-حerformance system for detecting novel altered regions of Hepatocellular carcinoma using high-throughput sequencing / |
| Statement of responsibility, etc. | Esraa Mamdouh Hashim Shabeb ; Supervised Ayman M. Eldeib , Mai Mohamed S. Mabrouk |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | نظام عالي الأداء للكشف عن مناطق تغيرات جديده لسرطان الكبد الوبائي باستخدام تسلسل عالي الانتاجيه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Esraa Mamdouh Hashim Shabeb , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 P. : |
| Other physical details | charts , maps, facsimiles ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Engineering - Department of Systems and Biomedical Engineering |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma(HCC) is a tumor of the liver which usually arises in the setting of chronic liver diseases. Fibrolamellar hepatocellular carcinoma (F- HCC) is a rare entity of HCC not yet analyzed cytogenetically. The use of high- performance parallel computing techniques can enable researchers to employ large numbers of processors to run comprehensive analyses within a reasonable period. This work provides a genomic study that focuses on using bioinformatics approaches to predict the molecular causes of HCC and F-HCC by the investigation whole genome sequence of the chromosomal aberrations using single nucleotide polymorphism (SNP)arrays and Next generation sequence (NGS) by applying four statistical techniques. The study revealed 3 distinct structural variations related genes MDM4, PRDM5, and WHSC1, these genes are a novel target signature that can help to predict survival of patients with detecting F-HCC. A new altered chromosome region amplification(4q22.1), this altered chromosomal region is novel for detect HCC, this finding has not previously reported being involved in liver carcinogenesis. NGS detect EPHA5, UBE1L2 tumor suppressor and UGT2B28 for both F-HCC and HCC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Next generation sequence |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Whole-genome sequencing |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman M. Eldeib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Mohamed S. Mabrouk , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.13.03.Ph.D.2017.Es.H | 01010110072943000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.13.03.Ph.D.2017.Es.H | 01020110072943000 | 22.09.2023 | CD - Rom | 72943.CD |