MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02532cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
171003s2017 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2017.Es.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Esraa Abdelmoneim Abdelmajeed Mostafa |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Design, synthesis and biological screening of pyrazole and pyrazolopyrimidine derivatives as anticancer agents / |
| Statement of responsibility, etc. |
Esraa Abdelmoneim Abdelmajeed Mostafa ; Supervised Ghaneya S. Hassan , Doaa E. Abdelrahman , Yassin M. Nissan |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تصميم و تشييد و مسح بيولوجى لمشتقات البيرازول و البيرازولوبيريميدين كمضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Esraa Abdelmoneim Abdelmajeed Mostafa , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
144 P. : |
| Other physical details |
photographs ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cancer is the second leading cause of death after cardiovascular complication with expectation of being first in coming few years. Accordingly, continued research is needed to develop new antitumor agents. Pyrazole or pyrazolopyrimidine scaffold is a very interesting bioactive core exhibiting several biological activities including anticancer, antimicrobial, antioxidant, antifungal and anti-inflammatory activities. In addition, sulfonamide functional moiety possessed good anticancer activity. Accordingly, new pyrazole or pyrazolopyrimidine derivatives bearing benzenesulfonamide moiety were designed and synthesized. The cytotoxic activities of the synthesized compounds against liver cancer cell line (HepG2) and breast cancer cell line (MCF7) were investigated. In addition, in vitro cell cycle analysis, apoptosis with its marker (caspase-3) and cyclin dependent kinase with its regulators (p21 and p27) were performed against the highly active compound to elucidate the possible mechanism of action. Furthermore molecular docking was established to predict the possible binding mode between the most active compound and the binding site in active site |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrazole |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrazolopyrimidine |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Sulfamoyl |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Doaa Ezat Abdelrahman , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ghaneya Sayed Hassan Ibrahim , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yassin Mohamed Nissan , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
