The possible pharmacological effects of combined administration with sitagliptin and quercetin in diabetic rats / (Record no. 62717)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03868cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031818.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171003s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.He.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hebatollah Elsayed Elsaied Abdelaal |
| 245 14 - TITLE STATEMENT | |
| Title | The possible pharmacological effects of combined administration with sitagliptin and quercetin in diabetic rats / |
| Statement of responsibility, etc. | Hebatollah Elsayed Elsaied Abdelaal ; Supervised Sanaa Abdelbaky Kenawy , Yousreya Aly Aly Maklad , Noha Fawzy Hamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ا{uئإؤئ}{uئإ٩٨}{uئإ٨٤}{uئإ٩آ}{uئآئئ}{uئإءإ}ات ا{uئإؤئ}{uئإءء}وا{uئإ٨آ}{uئآئئ}{uئإ٩٤} ا{uئإؤئ}{uئإإ٤}{uئإء٤}{uئإ٩٨}{uئإإ٤}{uئإإ٠}{uئآءآ} {uئإؤئ}{uئإإ٠}{uئإ٩٨}{uئإإ٨}{uئإ٨إ}ول ا{uئإؤئ}{uئإإ٤}{uئإ٩٨}{uئإآ٠}ا{uئإإ٣}{uئإإ٦} {uئإ٩١}{uئإآ٤}{uئآئئ}{uئإ٩٨}{uئإ٨إ}{uئإ٩ئ}{uئإإ٠}{uئآئئ}{uئإ٩٢}{uئإ٩٨}{uئآئئ}{uئإإ٦} و {uئإؤآ}{uئآئئ}{uئإءإ}{uئإآ٣}{uئآئئ}{uئإ٩٨}{uئآئئ}{uئإإ٦} فى ا{uئإؤئ}{uئإء٠}{uئإءإ}ذان ا{uئإؤئ}{uئإإ٤}{uئإآأ}{uئإ٨إ}{uئإ٩١}{uئآءآ} {uئإ٩١}{uئإإ٤}{uئإءإ}ض ا{uئإؤئ}{uئإآ٤}{uئإؤأ}{uئإءإ}ى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hebatollah Elsayed ElsSaied Abdelaal , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 188 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Type -II- diabetes mellitus prevalence and incidence is rapidly increasing worldwide; it is predicted, according to the latest estimates of the world health organization (WHO), that diabetes will be the 7th leading cause of death in 2030. The present study was constructed in order to investigate the possible beneficial anti-diabetic effect of simultaneous administration of quercetin (bioflavonoid, 50 mg/kg,p.o.) with either sitagliptin (DPP-IV inhibitor, 70 mg/kg,p.o) or gliclazide (10 mg/kg, p.o.) in streptozotocin (STZ, 45 mg/kg, i.p.) - induced type -II- diabetic rats. In order to achieve the goals of the present study, serum glucose, C-peptide, total cholesterol, triglycerides, malondialdehyde (MDA), tumor necrosis factor alpha (TNF-Ü) and adiponectin levels were measured at the end of the study period (3 consecutive weeks). In addition, histopathological, morphometrical and immunohistochemical examination of pancreas was conducted. Daily oral administration of diabetic rats with gliclazide significantly reduced serum glucose, MDA, TNF-Ü and significantly increased serum C-peptide and adiponectin levels, in addition normalized serum total cholesterol and triglycerides levels. Daily oral administration of sitagliptin or quercetin significantly reduced serum glucose, MDA and significantly increased serum C-peptide and adiponectin levels, as well as normalized serum total cholesterol, triglycerides and TNF-Ü levels. Moreover, all single treatments induced significant improvement in islet and beta cell parameters (number and size) and in the immunostaining intensity. Combined administration of quercetin with gliclazide ameliorated the hyperglycemia, as well as significantly increased the serum C-peptide level; in addition it normalized MDA, TNF-Ü and adiponectin levels |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetic rats |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Quercetin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sitagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Fawzy Hamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelbaky Kenawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yousreya Aly Aly Maklad , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.He.P | 01010110072907000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.He.P | 01020110072907000 | 22.09.2023 | CD - Rom | 72907.CD |