Preparation and characterization of biopolymeric nanoparticles as transdermal drug carriers for treatment of osteoarthritis on experimental animals / (Record no. 62787)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03644cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031821.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171007s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.04.Ph.D.2017.As.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Sayed Elhoussiny |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation and characterization of biopolymeric nanoparticles as transdermal drug carriers for treatment of osteoarthritis on experimental animals / |
| Statement of responsibility, etc. | Asmaa Sayed Elhoussiny ; Supervised Wafaa Mohamed Ahmed Khalil , Kamal Nasr Abdelnour , Salwa Louis Abdelmessieh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتوصيف بوليمرات نانومترية كحاملات ادوية من خلال الجلد لعلاج خشونة المفاصل على حيوانات التجارب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Sayed Elhoussiny , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 173 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Glucosamine sulfate (GS) has been used orally for the treatment of osteoarthritis however it may be susceptible to liver first pass phenomenon which greatly affects its bioavailability in addition to its side effects on the gastrointestinal tract. The aim of this study is to apply nanoencapsulation technologies using gelatin (Gel) and alginate (Alg) nanoparticles (NPs) as a new vehicle for transdermal delivery of GS to improve its effectiveness and reduce side effects. The GS-Gel and GS-Alg NPs were characterized through percentage yield, encapsulation efficiency, transmission electron microscope (TEM), particle size (DLS), zeta potential, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and dielectric spectroscopy. The in vitro release studies of GS and the ex vivo permeability through rat skin were determined using UV-VIS spectrophotometer. High drug encapsulation efficiency and nanoparticle yield were achieved for both Gel and Alg NPs. The TEM and DLS studies revealed that GS-Gel and GS-Alg NPs have small particle size in the nanometer size range. The zeta potential results indicated an initiation of electrostatic interaction occurred between GS, Gel and Alg NPs. FTIR studies showed a spectral change of the characteristic absorptions bands in both Gel and Alg NPs after encapsulation with GS. DSC data indicated changes in the thermal behavior of GS-Gel and GS-Alg NPs after the addition of GS. Furthermore, the dielectric study indicated an increase in the activation energy and the relaxation time of the 1st process in the GS-Gel and GS-Alg NPs suggesting the successful encapsulation of GS. The in vitro release studies showed that GS is released from Gel and Alg NPs in a sustained and prolonged manner. The ex vivo permeation of GS through rat skin increased for Gel NPs that contains 10% DMSO and enhanced significantly after encapsulation in the negatively charged Alg NPs. In this study, we successfully developed transdermal delivery nanosystem on an industrial scale using Gel and Alg NPs that permits the encapsulation of GS overcoming the disadvantages of oral administration |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gelatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glucosamine sulfate |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoarthritis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamal Nasr Abdelnour , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Louis Abdelmessieh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Mohamed Ahmed Khalil , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.04.Ph.D.2017.As.P | 01010110072967000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.04.Ph.D.2017.As.P | 01020110072967000 | 22.09.2023 | CD - Rom | 72967.CD |