Effect of melatonin and mesenchymal stem cells treatment on diabetic nephropathy in male rats / (Record no. 62892)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03355cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031824.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171014s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2017.La.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Mohamed Mahmoud Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of melatonin and mesenchymal stem cells treatment on diabetic nephropathy in male rats / |
| Statement of responsibility, etc. | Lamiaa Mohamed Mahmoud Ibrahim ; Supervised Samah Mohamed Elattar , Nashwa Eltablawy , Hend Ashour Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الميلاتونين والخلايا الجذعيه الوسيطة في علاج الاعتلال الكلوي في ذكور الجرذان المصايبه بداء السكري |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Lamiaa Mohamed Mahmoud Ibrahim , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 226 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Diabetes has become a widespread epidemic, including the increasing prevalence and incidence of type 1 diabetes. Diabetic nephropathy (DN) is a common complication of diabetes. In recent years, mesenchymal stromal cells (MSCs) have been highlighted as a new emerging regenerative therapy due to their multipotency, and paracrine secretion of angiogenic factors, cytokines, and immunomodulatory substances. MSCs may also have glucose lowering properties providing another attractive and unique feature of this therapeutic approach. MSC administration has significant potential in the treatment of DN but challenges remain in terms of engraftment, persistence, and tissue targeting. Melatonin seems to regulate signaling pathways that drive differentiation of MSC into different tissues. Objective: This study tried to evaluate the effects of melatonin or stem cells (especially those attenuated with melatonin) on streptozotocin induced DN in type 1 diabetic male rats. Methods: sixty adult male albino rats were divided into: Control group (I), diabetic group (II), diabetic + melatonin (III) group given melatonin intraperitoneal for 2 weeks after induction of diabetes, diabetic + stem cells (IV) group treated with stem cells a single dose by intravenous injection in rat tail vein after induction of diabetes and diabetic + stem cells attenuated with melatonin (V) group treated with stem cells after attenuation with melatonin ex vivo after induction of diabetes. At the end of the study period, GFR, BP, serum fasting blood glucose, serum insulin, plasma and urine creatinine level, Urea, urinary albumin excretion (UAE), serum angiotensin level, carboxymethyl lysine, kidney tissue level of : (tumor necrosis factor-alpha (TNF-Ü), Interleukin10 (IL- 10), Basic fibroblast growth factor (b-FGF), Super oxide dismutase), and glomerular expression of (TGF-Ý, Bcl-2, Beclin) were measured |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | diabetic nphropathy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Melatonin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MSCs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hend Ashour Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nashwa Eltablawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samah Mohamed Elattar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2017.La.E | 01010110072985000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2017.La.E | 01020110072985000 | 22.09.2023 | CD - Rom | 72985.CD |