Lymphangiogenesis in oral squamous cell carcinoma, correlation with VEGF-C expression and lymph node metastasis : Immunohistochemical and RT-PCR study : (Record no. 63063)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02983cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031829.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171022s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.13.Ph.D.2016.Ma.L |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manar Abdulwaniss Mohammed Abdulaziz |
| 245 10 - TITLE STATEMENT | |
| Title | Lymphangiogenesis in oral squamous cell carcinoma, correlation with VEGF-C expression and lymph node metastasis : Immunohistochemical and RT-PCR study : |
| Remainder of title | In vitro study / |
| Statement of responsibility, etc. | Manar Abdulwaniss Mohammed Abdul-Aziz ; Supervised Amina Kamel , Dalia Hussein Elrouby , Olfat Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ارتباطا بظهوروتكوين الأورام الثانوية في الغدد اللمفاويةVEGF-Cنمو الأوعية الليمفاوية في سرطان الخلايا القشرية الفمية : |
| Remainder of title | دراسة معملية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Manar Abdulwaniss Mohammed Abdulaziz , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 167P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy that preferentially spreads to the cervical lymph node which, when involved, complicates the anticancer therapy and threatens the patient life. It was suggested that lymph node (LN) metastasis may be facilitated by lymphangiogenesis. VEGF C is one of the most important lymphangiogenic inducers that promotes the lymphatic vessels growth and supports the survival of adult lymphatic endothelial cells. Methods: Lymphatic vessels density (LVD) and LV morphometry were digitally evaluated using D2-40. The expression of VEGF C was also assessed using immunohistochemistry (IHC) and real time polymerase chain reaction (RT-PCR) in 6 normal oral mucosa and 72 cases of OSCC. The correlation between LVD and LV morphometry, VEGF C and lymph node metastasis were done. Results: A positive cytoplasmic expression of VEGF C was detected in both epithelial and connective tissue cells in 97% of OSCC while all normal tissues negatively reacted. A greater expression of VEGF C was associated with larger and more dilated LV and lymph node metastasis but not with LVD. Conclusion: VEGF C is actively involved in the invasion and metastasis of OSCC via inducing morphological changes in LV. VEGF C, being almost absent in normal tissue, may be a promising target for anticancer therapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lymphangiogenesis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oral squamous cell carcinoma (OSCC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | VEGF-C |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amina Kame , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Hussein Elrouby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.13.Ph.D.2016.Ma.L | 01010110073009000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.13.Ph.D.2016.Ma.L | 01020110073009000 | 22.09.2023 | CD - Rom | 73009.CD |