Evaluation of the protective effect of taurine, seleno l-methionine and l-carnitine against acetaminophen-induced hepatotoxicity in rats / (Record no. 63130)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03748cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031831.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171024s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Ne.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nermeen Elsaeed Mansour Elsharkawy |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the protective effect of taurine, seleno l-methionine and l-carnitine against acetaminophen-induced hepatotoxicity in rats / |
| Statement of responsibility, etc. | Nermeen Elsaeed Mansour Elsharkawy ; Supervised Ezz Eldin Eldenshary , Hala Fahmy Zaki , Wafaa Eleraky |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثير الوقائي لكل من تورين ولينو أل - مثيونين وأل - كارنتين من التسمم الكبدي المحدث بواسطة - أسيتامينوفين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nermeen Elsaeed Mansour Elsharkawy , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 195 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacologya and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Paracetamol (APAP) is a commonly used analgesic and antipyretic. Toxic doses of APAP, however, cause massive hepatocellular apoptosis and necrosis. Taurine (TAU) is an essential amino acid that possesses a number of cytoprotective properties through its actions as an antioxidant, anti-apoptotic and intracellular calcium flux regulator. Seleno L-methionine (Se-met) it is source of selenium (Se) that increases the activity of glutathione peroxidase. The major antioxidant role of glutathione peroxidase in liver cells is to maintain appropriately low levels of hydrogen peroxides via glutathione reductase and convert it to water, thus decreasing potential free radical damage. L-carnitine (CAR) is a mitochondria-specific antioxidant that plays an important role in oxidative/antioxidative balance by scavenging reactive oxygen species and increasing ATP production. Aim of the study: The present work was designed to examine the possible protective effects of TAU, Se-met and CAR against APAP -induced liver injury. Method: Male Wistar rats were allocated into eight groups of 10 animals each. Group I received saline p.o. for 7 days (normal group), group II received TAU (200 mg/kg; p.o.) for 7 days , group III received Se-met (0.4 mg/kg; p.o.) for 7 days , group IV received CAR (300 mg/kg; p.o.) for 7 days, group V received saline for 7 days followed by a single dose of APAP (700 mg/kg; p.o.) on the 8th day (APAP control group), group VI received TAU (200 mg/kg; p.o.) .) for 7 days followed by APAP, group VII received Se-met (0.4 mg/kg; p.o.) .) for 7 days followed by APAP and group VIII received CAR (300 mg/kg; p.o.) for 7 days followed by APAP on the 8th day group. Rats were sacrificed 24 h thereafter. Parameters used to assess the protective effect of TAU, Se-met and CAR included serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities as well as liver contents of thiobarbituric acid reactive substances, reduced glutathione, nitric oxide, total antioxidant capacity, tumor necrosis factor-alpha and transforming growth factor- beta in addition to histological examination of liver sections from all studied groups |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Paracetamol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Seleno l-methionine and L-carnitine oxidative stress |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Taurine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Eleraky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.E | 01010110073018000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.E | 01020110073018000 | 22.09.2023 | CD - Rom | 73018.CD |