Expression of B and T iymphocyte attenuator, retinoid-related orphan receptor gamma-Isoform-t and interleukin 7 in psoriasis vulgaris / (Record no. 63339)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03053cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031838.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171107s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2017.Na.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nadia Mohamed Shoukry |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of B and T iymphocyte attenuator, retinoid-related orphan receptor gamma-Isoform-t and interleukin 7 in psoriasis vulgaris / |
| Statement of responsibility, etc. | Nadia Mohamed Shoukry ; Supervised Randa Mohammad Youssef , Amany Zaki Elramly , Marwa Fathy Hussein |
| 246 1# - VARYING FORM OF TITLE | |
| Title proper/short title | و انترلوكين7 فى الصدفيه التقليدية T الليمفاوية: مستقبل ريتينويد ذات الصلة جاما T و B التعبير الجينى لمضاعفات خلايا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nadia Mohamed Shoukry , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Psoriasis is one of the immune-mediated inflammatory diseases (IMID); Both CD4⁺ T lymphocytes mainly Th1 cells and B lymphocytes contribute in the pathogenesis of IMIDs through the proinflammatory effect and production of antibodies, activation of T cells, cytokine synthesis respectively. Gamma delta (Þe) T cells are capable of producing large amounts of IL-17 upon IL-23 stimulation. The capacity of Þe T cells to produce IL-17 is acquired during thymic differentiation, independent of TCR signaling, a feature pointing to their innate nature. B and T lymphocyte attenuator (BTLA) is a coinhibitory molecule expressed on T and B lymphocytes as well as other immune cells, it is necessary to inhibit homeostatic expansion and activation of lymph node and skin resident Þe T cells. BTLA expression is regulated by RORÞt and IL-7. RORÞt is a key transcription factor driving the Th17 differentiation producing IL-17 which plays a major role in psoriasis pathogenesis. IL-7 plays a role in psoriasis pathogenesis and is also critical for the normal homeostasis, function, expansion, and survival of adult Þe Tcells. Aim of study: To add more insight to the role played by co-inhibitory molecule BTLA in psoriasis vulgaris patients, by studying the gene expression of BTLA, RORÞt and IL-7 in psoriasis patients. It also aimed to analyze their inter-relationship. This aims at establishing a basis for novel treatment strategies for psoriasis. Patients and methods: This case control study included 25 patients and 25 controls examined for gene expression of BTLA, RORÞt and IL-7 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BTLA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Psoriasis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Þe T cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Zaki Elramly , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Fathy Hussein , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Randa Mohammad Youssef , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2017.Na.E | 01010110073299000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2017.Na.E | 01020110073299000 | 22.09.2023 | CD - Rom | 73299.CD |