Pathological studies on induced hepatic cirrhosis with evaluation of some hepatoprotective materials / (Record no. 63350)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03438cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031838.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171108s2017 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.05.Ph.D.2017.As.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Khairy Mohammed Almokaddem |
| 245 10 - TITLE STATEMENT | |
| Title | Pathological studies on induced hepatic cirrhosis with evaluation of some hepatoprotective materials / |
| Statement of responsibility, etc. | Asmaa Khairy Mohammed Almokaddem ; Supervised Kawkab Abdelaziz Ahmed , Sahar Samir Mahmoud |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات باثولوجية على التليف الكبدى المستحدث فى الجرذان مع تقييم بعض المواد الواقية للكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Khairy Mohammed Almokaddem , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 184 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study was carried out to investigate thioacetamide (TAA)-induced cirrhosis with evaluation of some natural materials with hepatoprotective nature. Three hundred adult male sprague-dawely rats were allocated into 10 equal groups (30 rats each) and kept under standard hygienic conditions 6 animals{u2019} {u0338} cage. Group I served as control negative group, group II, III, IV and V were administered silymarin (100mg{u0338} Kg b.wt), propolis (100mg{u0338} Kg b.wt), spirulina (300mg{u0338} Kg b.wt) and naringenin (50mg{u0338} Kg b.wt)respectively by oral gavage daily to serve as tested hepatoprotective materials control groups, group VI was intraperitoneally injected by TAA at a dose of 200mg{u0338} kg b.wt. twice a week, while groups VII, VIII, IX and X were administered silyrmarin, propolis, spirulina and naringenin respectively with concurrent injection with TAA at the previously mentioned doses. Every two weeks, animals body weights in each group was recorded and five animals from each group were sacrificed, blood samples were collected for serum separation to perform liver function markers (AST, ALT, ALP and bilirubin) and kidney function markers tests (BUN and creatinine). Liver, kidneys and brain specimens were collected for histopathology and the hepatocarcass index was calculated. The oxidative status of liver homogenate was evaluated by measuring MDA and SOD levels. Fibrosis scoring was done according to the METAVIR scoring system, immunostaining for caspase-3 and Ü-SMA were also performed. TAA administration resulted in significant elevation of serum liver and kidney function markers when compared to the control negative group, while concurrent administration of the different tested hepatoprotective materials with TAA injection resulted in variable significant ameliorative effect on their elevation. Concurrent administration of the different tested hepatoprotective materials with TAA administration had a significant improving effect on the oxidative status of the liver by significant lowering MDA levels and increasing SOD activity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver cirrhosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Propolis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thioacetamide |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kawkab Abdelaziz Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sahar Samir Mahmoud , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.05.Ph.D.2017.As.P | 01010110073405000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.05.Ph.D.2017.As.P | 01020110073405000 | 22.09.2023 | CD - Rom | 73405.CD |