MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02861cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171108s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.02.Ph.D.2017.Ta.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Taghried Mahmoud Ibrahim Hellaly |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Circulating microRNAs, miR-143, miR-100 and miR-92, as non-invasive biomarkers for bladder cancer diagnosis / |
| Statement of responsibility, etc. |
Taghried Mahmoud Ibrahim Hellaly ; Supervised Tarek Mohamed Motawi , Sherine Maher Rizk , Ihab abdel Rahman Ibrahim |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
ميكرو أر إن إيه 143: ميكرو أر إن إيه 100و ميكرو أر إن إيه 92 كدلائل حيوية غير غازية لتشخيص سرطان المثانة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Taghried Mahmoud Ibrahim Hellaly , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
121 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers. Recent advantages of serum miRNAs open a new realm of possibilities for noninvasive diagnosis and prognosis of bladder cancer (BC). The aim of our study was to identify plasma miR-92a, miR-100 and miR-143 expression signatures in patients with BC to introduce new markers for establishing BC diagnosis and prognosis. Blood samples were collected from 70 BC patients and 62 controls. Expression of 3 target miRNAs (miR-92a, miR-100 and miR-143) was measured using a quantitative real-time PCR method. The results were correlated with clinicopathological data and analyzed. Plasma levels of miR-92a, miR-100, and miR-143 were significantly lower in BC patients than in the control group. Receiver operator characteristic (ROC) analysis revealed that the sensitivity and specificity values of miR-92a were 97.1% and 76.7%, respectively, with a cut-off value of 0.573. The sensitivity and specificity values of miR-100 were 90% and 66.7%, respectively, with a cut-off value of 0.644. The sensitivity and specificity values of miR-143 were 78.6% and 93.3%, respectively, with a cut-off value of 0.164. This study explores the existence of specific plasma miRNAs as early diagnostic biomarkers for BC in Egyptian patients; and these findings suggest that plasma miR-92a, miR-100 and miR-143 could be a promising novel circulating biomarkers in clinical detection of BC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Bladder cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MicroRNA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Molecular marker |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ihab abdel Rahman Ibrahim , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sherine Maher Rizk , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tarek Mohamed Motawi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
