MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03048cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
171111s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2017.Da.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Ali Farghaly Ibrahim |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Preparation of an anti-inflammatory drug in different dosage forms for topical application / |
| Statement of responsibility, etc. |
Dalia Ali Farghaly Ibrahim ; Supervised Magdy Ibrahim Mohamed , Ahmed Abdelfattah Aboelwafa , Manal Yassin Hamza |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تحضير عقار مضاد للالتهاب فى أشكال صيدلية مختلفة للاستعمال السطحى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Dalia Ali Farghaly Ibrahim , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
184 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The aim of this study was to formulate fenoprofen calcium (FPCa) in different topical dosage forms; namely microemulsion and spanlastic gel to eliminate its oral gastrointestinal adverse effects. Microemulsion was prepared by the water titration method using oleic acid as oil phase, tween 80 or cremophor EL as surfactants and propylene glycol or transcutol P as cosurfactants. Oleic acid was selected as oil phase due to its good solubilizing capacity. Microemulsion existence region was determined using pseudo-ternary phase diagrams for preparing different formulations. Six different formulations were selected with various values of oil (25-68%), water (2-3%), and the mixture of tween 80 and propylene glycol (1:1) (24-67%). The selected microemulsion formulae were characterized for optical birefringence, transmission electron microscopy, pH, % transmittance, electronic conductivity, drug content, droplet size, rheological properties and stability evaluation. In-vitro release study of fenoprofen calcium from microemulsions through the synthetic membrane and hairless rat skin were evaluated. The optimized formula ME5 consisting of 5% w/w fenoprofen calcium, 60% w/w oleic acid as oil phase, 3% w/w aqueous phase, and 32% w/w of surfactant phase containing Tween 80 and propylene glycol (1:{u2009}1) showed the highest transdermal flux and highest skin permeation rate. FPCa-loaded spanlastics were prepared by thin-film hydration (TFH) technique according to a full factorial design (23) to investigate the influence of formulation variables on the drug entrapment efficiency (%EE), particle size (PS), deformability index (DI), and the % drug released after 24hs through the cellulose membrane (Q24h) using design-expert® software |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Fenoprofen calcium |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Microemulsion |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Topical delivery |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Abdelfattah Aboelwafa , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Magdy Ibrahim Mohamed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Yassin Hamza , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
