Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma in HCV patients / (Record no. 63403)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02995cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031839.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171112s2017 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.19.Ph.D.2017.Es.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Essraa Adel Aly Aly Hegazy |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of serum protein markers in diagnosis of hepatocellular carcinoma in HCV patients / |
| Statement of responsibility, etc. | Essraa Adel Aly Aly Hegazy ; Supervised Somaia Abdellatif Eissa , Ashraf Elsayed Abdelhamid , Hanan Hassan Fouad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم علامات البروتين فى مصل الدم لتشخيص سرطان الكبد لمرضى الكبد المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Essraa Adel Aly Aly Hegazy , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 154 Leaves ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma (HCC) is the fifth most common cancer, the third most common cause for cancer death in the world, the major cause of death in patients with chronic hepatitis C virus infection, and responsible for approximately one million deaths each year. Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus is a major risk for the development of HCC. Because outcomes with HCC are likely to be improved by early detection, better serologic tools for early detection are needed, therefore, there is an urgent need to develop new therapeutic targets and to identify novel biomarkers for the early detection of HCC before any breakthrough in HCC clinical management can be achieved which drives our thinking towards proteomics analysis for screening of HCC and cirrhotic HCV patients. This study was done to assess the diagnostic value of the protein markers in both cirrhotic patients on top of HCV and in HCC patients on top of HCV in comparison to normal controls by serum analysis for alpha feto protein, Apo A1, ApoA2, IGF1 and IGF1R by westeren blotting technique. It was found that alpha feto protein alone could not be used alone as a screening test while Apo A2 as a serum marker could be used as a non invasive screening test to differntiate a case of HCC from cirrhotic HCV patient. The all four markers were able to discriminate nomal persons from HCC and cirrhotic HCV patients effectively. We concluded that proteomics analysis being non invasive, rapid and sensitive is a novel gate that can serve in early dignosis and screening of HCC and cirrhotic HCV patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cirrhosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCV |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashraf Elsayed Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hassan Fouad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somaia Abdellatif Eissa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.19.Ph.D.2017.Es.E | 01010110073432000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.19.Ph.D.2017.Es.E | 01020110073432000 | 22.09.2023 | CD - Rom | 73432.CD |