The possible cardioprotective effect of Geraniol in experimentally-induced myocardial ischemia / reperfusion injury / (Record no. 63498)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03209cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031842.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171116s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Ne.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nermein Fawzy Elsayed Abdelmaksoud |
| 245 14 - TITLE STATEMENT | |
| Title | The possible cardioprotective effect of Geraniol in experimentally-induced myocardial ischemia / reperfusion injury / |
| Statement of responsibility, etc. | Nermein Fawzy Elsayed Abdelmaksoud ; Supervised Hanan Salah Eldin Elabhar , Azza Sayed Awad , Hesham Mohammed Mahmoud |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور الجيرانيول المحتمل فى الوقاية من نقص الدم و إعادة التروية المحدث تجريبياً في عضلة القلب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nermein Fawzy Elsayed Abdelmaksoud , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 168 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy- Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Ischemic heart disease is a leading cause of death in human population and protection against ischemia-reperfusion (I/R) injury associated with myocardial infarction (MI) remains a challenge. So, cardio-protection against I/R injury should be considered. Geraniol is acyclic monoterpene with multiple pharmacological activities. However, its possible protective role in myocardial I/R Injury has not been elucidated. Aim: This study investigates the protective effect of Geraniol alone or in combination with Coenzyme Q10 in experimentally induced cardiac I/R injury. Method: Fifty rats were divided into five groups (n=10), Sham, I/R, geraniol and/or coenzyme Q10. Left anterior descending coronary artery was ligated for 30 minutes then released. The success of the model was assured by carrying out ECG before and all through the experiment. After reperfusion for 120 minutes, blood Samples were collected and the heart was excised detecting the infarct area and for further histopathological and biochemical analysis. Results: I/R injury group showed significant decrease in levels of SOD, Bcl2, GSK-3Ý and Ý-catenin as well as increased levels of TNF-Ü, Nf-KB, ICAM-1, Mpo, CK-MB, LDH, and cTn-1. While Pre-treated groups showed significant improvement of all biochemical parameters. These results were confirmed by histopathological examination as well as detecting the percent of infarct area of the area at risk. Conclusion: Geraniol or coQ10 significantly protected the heart via their antioxidant, anti-inflammatory and anti-apoptotic potential, while the combination almost normalized the biochemical levels and histopathological data. So, they can be considered as promising cardioprotective drugs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Coenzyme Q10 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Geraniol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Myocardial ischemia / reperfusion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Sayed Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hesham Mohammed Mahmoud , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.P | 01010110073202000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Ne.P | 01020110073202000 | 22.09.2023 | CD - Rom | 73202.CD |