Development of anti-inflammatory drugs from traditional medicine guided by virtual screening / (Record no. 63563)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03477cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031844.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171119s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.07.M.Sc.2017.Ab.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abdullah Abdurrahman Gaber Elgazar |
| 245 10 - TITLE STATEMENT | |
| Title | Development of anti-inflammatory drugs from traditional medicine guided by virtual screening / |
| Statement of responsibility, etc. | Abdullah Abdurrahman Gaber Elgazar ; Supervised Hala Mohamed Elhefnawy , Nabil Mohie Abdelhamid , Nabil Mohamed Aboelfotouh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تطوير عقاقير مضادة للالتهاب من الطب التقليدي باستخدام التحرى الافتراضى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Abdullah Abdurrahman Gaber Elgazar , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 224 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Inflammation is one of the main causes of the pathogenesis of several chronic diseases, which make the discovery of new safe and effective medicine an urgent need, this thesis aims at the access the anti-inflammatory mechanism of traditional medicine using virtual screening, especially those whose ability to inhibit the p38 mitogen activate protein kinase which play an important role in pathogenesis of inflammation. This thesis is divided to 4 chapters Chapter I: Pathogenesis of inflammation. Studying the molecular pathway of inflammation, raised our attention to the role of p38 MAP Kinase the development of inflammatory diseases, which means that inhibiting this enzyme could help in developing effective anti-inflammatory drugs. Chapter II: Virtual screening of traditional medicine database. In this chapter, Traditional medicine database containing approximately 60000 compounds was subjected to ADME Filtration, which subsequently led to the reduction of compounds number to 5000. High through-put molecular docking was used to identify the best 100 compounds based on their ability to bind with the enzyme, the virtual screening revealed that these compounds were chemically classified as Diarylheptanoids, Flavonoids and anthraquinones. Nine representative compounds were selected for isolation from their respective resources, after consulting different database, these compounds were found to be in lesser galangal rhizomes, Turmeric rhizomes, Rhubarb rhizomes and citrus fruit. Chapter III: Isolation of the active compounds In this chapter, we addressed the isolation of the compounds under investigation using different chromatographic methods, their structure elucidation was done using spectroscopic methods in addition to comparison to published data, and the compounds were 1-Galangin 2- Kaempferide 3- (7-(4''- hydroxy-3''-methoxyphenyl)-1-phenylhept-4-en-3-one). 4- (5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one) 5- Isorhamnetin. 6-Curcumin 7-Physcion 8-Chrysophanol 9-Hesperidin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-inflammatory drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | P38 mitogen activated protein kinase |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Traditional medicine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Mohamed Elhefnawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nabil Mohamed Aboelfotouh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nabil Mohie Abdelhamid , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.07.M.Sc.2017.Ab.D | 01010110073343000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.07.M.Sc.2017.Ab.D | 01020110073343000 | 22.09.2023 | CD - Rom | 73343.CD |