Role of vascular endothelial growth factor (VEGF+963 C>T) and basic fibroblast growth factor (bFGF-921C>G) gene polymorphisms in B-Cell chronic lymphocytic leukemia / (Record no. 63707)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03134cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031848.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171127s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2017.Ra.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rasha Fawzy Ahmed Elsebaey |
| 245 10 - TITLE STATEMENT | |
| Title | Role of vascular endothelial growth factor (VEGF+963 C>T) and basic fibroblast growth factor (bFGF-921C>G) gene polymorphisms in B-Cell chronic lymphocytic leukemia / |
| Statement of responsibility, etc. | Rasha Fawzy Ahmed Elsebaey ; Supervised Hoda Mohamed Abdelghany , Nadia Ibrahim Sewelam , Noha Yehia Abdou Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعدد الشكلى لجين عامل نمو الخلايا المبطنه للأوعيه الدمويه و جين عامل نمو الخلايا الليفيه الأساسى فى سرطان الدم الليمفاوى المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rasha Fawzy Ahmed Elsebaey , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 159 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) dependent angiogenesis in chronic lymphocytic leukemia (CLL) have been reported in several studies. Single nucleotide polymorphisms (SNPs) in VEGF and bFGF genes could regulate their cellular expression and consequently affect CLL disease progression. Aim of work: The aim of the present study was to determine the relation between VEGF+936 C>T and bFGF-921 C>G polymorphisms and B-CLL disease severity. Material and methods: The study was conducted on 50 CLL patients and 50 age and sex matched healthy adults. Polymerase chain reaction restriction fragment length Polymorphism (PCR-RFLP) technique was performed for the detection of VEGF+936 C>T and bFGF-921 C>G polymorphisms. Results: VEGF mutant genotypes (CT and TT), allele (T), and bFGF mutant genotypes (CG and GG), allele (G) were slightly higher among CLL patients compared to controls, with no statistical significance (p-value =0.414, 0.298, 0.422 and 0.524). No difference in VEGF and bFGF allele or genotype distribution was detected between subgroups with stages 0-II versus III-IV according to Rai staging (p-value =0.243 and 0.909). Conclusion: our study did not detect significant relationships for VEGF or bFGF polymorphisms and susceptibility to B- CLL or progression of the disease. Relating the VEGF and bFGF polymorphisms in future studies to the corresponding growth factor gene expression and plasma levels is advised to clarify association with disease pathophysiology and disease progression |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CLL |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genetic polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | VEGF |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mohamed Abdelghany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Ibrahim Sewelam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Yehia Abdou Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2017.Ra.R | 01010110073604000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2017.Ra.R | 01020110073604000 | 22.09.2023 | CD - Rom | 73604.CD |