The role of prolactin receptor in ovarian tumours / (Record no. 63894)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03071nam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031853.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171209s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.04.Ph.D.2017.Ne.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nesreen Mohamed Magdy Mahmoud Abdulgawad |
| 245 14 - TITLE STATEMENT | |
| Title | The role of prolactin receptor in ovarian tumours / |
| Statement of responsibility, etc. | Nesreen Mohamed Magdy Mahmoud Abdulgawad ; Supervised Magda Mourad Elsayed Hassan , Mohamed Akram Nouh , Mona Ali Sakr |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور مستقبلات البرولاكتين فى أورام المبيض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nesreen Mohamed Magdy Mahmoud Abdulgawad , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 184 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncologic (Pathology) |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Ovarian cancer is the 7th commonest cancer in women and is considered the most lethal gynecologic malignancy. Chemo-resistance is the major obstacle for the treatment of ovarian cancer. With the adopted treatment strategies, up to 90% of patients suffer relapse. The role of Prolactin (PRL)/ Prolactin Receptor (PRL-R) signaling has been suggested in many types of cancer and some studies suggested that PRL opposes cytotoxicity of many anticancer drugs. Material and Methods We investigated the profile and significance of expression of PRL-R and all its ligands in 503 ovarian surface epithelial tumours and cell lines by immunohistochemistry (IHC) and Western blotting and we studied the effect of PRL-R knockdown and antagonism on the viability, apoptosis and response to chemotherapy in ovarian HGSC cell lines. Results PRL-R is expressed in all cases of ovarian tumours by and both long and short PRL-R isoforms are expressed in HGSC cell lines. At least one of the three ligands (PRL, GH or PL) was expressed in 92.4% of the cases and they tend to be co-localized. Malignant tumours with epithelial PRL expression show shorter overall survival than tumours with no expression. The three ligands expression is higher in patients below 30 years old while the PRL-R expression is stronger in patients above 50 years old. In PEA1 cell line, PRL-R antagonism in combination with cisplatin shows decreased cell viability but not enhance apoptosis. The same effects are observed with the receptor knockdown with or without cisplatin. In PEO1 cell line, PRL-R antagonism in combination with cisplatin shows enhanced apoptosis, while PRL-R shRNA alone and in combination with cisplatin shows both decreased cell viability and enhanced apoptosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ovarian Tumours |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Prolactin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Prolactin Receptor |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda Mourad Elsayed Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Akram Nouh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Ali Sakr , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.04.Ph.D.2017.Ne.R | 01010110073732000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.04.Ph.D.2017.Ne.R | 01020110073732000 | 22.09.2023 | CD - Rom | 73732.CD |