Ultrastructural study of mitochondrial changes in relation to carbamoyl phosphate synthetase1 in different stages of hepatitis C virus infection / (Record no. 63896)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03153cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171209s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.Ph.D.2017.Ra.U |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ranya Mohamed Magdy Elsheikh |
| 245 10 - TITLE STATEMENT | |
| Title | Ultrastructural study of mitochondrial changes in relation to carbamoyl phosphate synthetase1 in different stages of hepatitis C virus infection / |
| Statement of responsibility, etc. | Ranya Mohamed Magdy Elsheikh ; Supervised Ali Ahmed Fouad Elhindawi , Soheir Saiid Mansy , Hala Naguib Hosni |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة باستخدام الميكروسكوب الإلكترونى لتغيرات الفيتوكوندريا فى حالات الإلتهاب الكبدى الفيروسى سى و علاقتها بإنزيم البناء لفوسفات الكربامويل ١ فى المراحل المختلفة للمرض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ranya Mohamed Magdy Elsheikh , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatitis C virus (HCV) is a global pathogen and a leading cause of morbidity and death. Epidemiological evidence highlights chronic HCV infection as the main cause of cirrhosis, hepatocellular carcinoma as well as other extrahepatic diseases. Meanwhile, histological evaluation of liver biopsy is the principal method used for assessing the severity of liver disease. Efforts are being exerted to replace liver biopsy with alternative non-invasive methods. HCV is known to target mitochondria, therefore mitochondrial dysfunction is anticipated to be a cornerstone in hepatic disease progression. In this light, a unique, liver-specific intramitochondrial enzyme, carbamoyl phosphate synthetase 1 (CPS1), could be useful in the prognosis of hepatic disease. Aim of the work: This study aimed at quantifying CPS1 in the serum of patients at different stages of chronic hepatitis C in relation to liver tissue CPS1 and mitochondrial counts, using light (LM) and electron microscopy (EM) respectively. This would assess its value as a marker of mitochondrial dysfunction and liver disease progression in chronic hepatitis C patients. Materials and methods: This research included 72 different HCV chronically infected patients and 15 healthy controls. Percutaneous liver biopsies were collected and processed for LM and EM examination. Group (F1+F2) represented moderate fibrosis and group (F3+F4) represented severe fibrosis. Blood samples were collected for tests including CBC, platelet count, PT, ALT, AST, total bilirubin, albumin and urea using the standard kits. In addition, serum CPS1 was evaluated using ELISA |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CPS1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Electron microscopy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ali Ahmed Fouad Elhindawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Naguib Hosni , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Saiid Mansy , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.Ph.D.2017.Ra.U | 01010110073674000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.Ph.D.2017.Ra.U | 01020110073674000 | 22.09.2023 | CD - Rom | 73674.CD |