Evaluation of the possible hepatoprotective effects of coenzyme Q10 and alpha-lipoic acid against lipopolysaccharide-induced liver injury in rats / (Record no. 63918)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03330cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031854.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171209s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2017.Am.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amr Mohamed Emam Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the possible hepatoprotective effects of coenzyme Q10 and alpha-lipoic acid against lipopolysaccharide-induced liver injury in rats / |
| Statement of responsibility, etc. | Amr Mohamed Emam Mohamed ; Supervised Hala Fahmy Zaki , Hala M. Fawzy , Olfat Gamil Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثيرات الوقائية المحتملة لكو إنزيم كيو 10 وحمض ألفا- ليبويك في إصابة الكبد المحدثة بواسطة متعددات السكريات الدهنية في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amr Mohamed Emam Mohamed , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 138 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Lipopolysaccharide (LPS) is the major cell wall component of gram-negative bacteria known to stimulate the synthesis and secretion of several toxic metabolites, such as reactive oxygen species and cytokines. In this study, the protective effect of alpha-lipoic acid (ALA) and coenzyme Q10 (CoQ10) were evaluated in LPS-induced hepatic injury in rats. To this end, male adult Sprague Dawley rats were divided into five groups; normal control, LPS control where rats were injected with an initial dose of LPS (4 mg/kg; i.p.) on the 1stday of the experiment followed by a challenging dose (2 mg/kg; i.p.) on the 8th day, ALA (50 mg/kg), CoQ10 (10 mg/kg) and ALA plus CoQ10. Treatments continued for 15 days and the last three groups also received LPS. At the end of the study, liver function tests, as well as interleukin-6 (IL-6) were estimated in serum. Liver lipid peroxides measured as malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and total antioxidant capacity (TAC) were also assessed, in addition to histological examination of liver sections from all groups. The obtained data revealed that LPS markedly elevated activities of serum aminotransferases, alkaline phosphatase and gamma-glutamyl transferase, as well as, total bilirubin and interleukin-6 levels. LPS-treated rats showed an increase in MDA liver content versus decrease in GSH content, SOD activity and TAC. Oral administration of ALA, CoQ10 and their combination ameliorated LPS-induced increases in liver function enzymes and IL-6, coupled by hampering of oxidative biomarkers. This was also supported by histopathological evaluation results. In conclusion, administration of ALA, CoQ10 and their combination improved pathological abnormalities in liver tissues and reversed the deleterious effects induced by LPS |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alpha-lipoic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Co-enzyme Q10 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala M. Fawzy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2017.Am.E | 01010110073738000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2017.Am.E | 01020110073738000 | 22.09.2023 | CD - Rom | 73738.CD |