MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03263cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171217s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.11.18.M.Sc.2017.Ha.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hamida Abdelfattah Elazab Ali |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Estimation of toll like receptors 2, 9 (TLR2 & TLR9) gene polymorphism in TYPE 2 DM patients with diabetic foot / |
| Statement of responsibility, etc. |
Hamida Abdelfattah Elazab Ali ; Supervised Mohamed Naguib Abdallah , Rasha Hamed Elsherief , Maha Assem Hussien |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
في مرضى السكر من النوع الثانى المصابين بالقدم السكرى TLR2 & TLR9 تحديد التغيرات الجينية بالمستقبلات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Hamida Abdelfattah Elazab Ali , |
| Date of publication, distribution, etc. |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
127 P. : |
| Other physical details |
charts , facsimilesm ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: Systemic inflammation plays a role in the pathogenesis of Diabetes Mellitus (DM) complications via innate immune receptors. Toll-like receptors (TLRs) are the key immune receptors that mediate the inflammatory response in DM. Aim of the study: to evaluate the association of TLR2 and TLR9 gene polymorphism in patients with type 2 DM and diabetic foot. Patients and methods: the study included three groups, group I: 30 patients of type 2 DM with diabetic foot, group II: 30 patients of type 2 DM without diabetic foot and group III: 30 normal individuals as control subjects. TLR2 (1350 T/C, rs3804100) and TLR9 (1237 T/C, rs5743836) genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique for all the groups. Results: The frequency of TLR9-1237 T/C polymorphic genotypes in group I (DM with diabetic foot) was 73.3 % for the heteromutant genotype (TC) and 6.7 % for the homomutant (CC). There was statistical significant difference in the distribution of TLR9-1237 T/C genotypes between group I (DM with diabetic foot) and group II (DM without diabetic foot) with p-value < 0.001 as well as between group I (DM patients with diabetic foot) and group III (control) with p-value < 0.05. Calculated risk estimation revealed that TLR9-1237 polymorphism (TC & CC) conferred almost twenty times increased risk of diabetic foot (odds ratio (OR) = 20, 95 %, confidence interval (CI) = 5.38-74.30). As for TLR2-1350 T/C, the frequency of the heteromutant genotype (TC) was 3.3 % with no homomutant genotype (CC) in diabetic patients with diabetic foot. There was no statistical difference in the distribution of TLR2-1350T/C genotypes between the three groups. Conclusion: The study revealed that TLR9-1237 T/C polymorphism may be considered as a molecular risk for diabetic foot among patients with type 2 diabetes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Diabetic foot |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Toll-like receptors |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Type 2 DM |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Maha Assem Hussien , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Naguib Abdallah , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rasha Hamed Elsherief , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
